Toxicity of Shiga toxin 1 in the central nervous system of rabbits

J. Fujii; Y. Kinoshita; T. Yutsudo; H. Taniguchi; T. Obrig; S. I. Yoshida

doi:10.1128/IAI.69.10.6545-6548.2001

Toxicity of Shiga toxin 1 in the central nervous system of rabbits

J. Fujii, Y. Kinoshita, T. Yutsudo, H. Taniguchi, T. Obrig, S. I. Yoshida

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The action of Shiga toxin (Stx) on the central nervous system was examined in rabbits. Intravenous Stx1 was 44 times more lethal than Stx2 and acted more rapidly than Stx2. However, Stx1 accumulated more slowly in the cerebrospinal fluid than did Stx2. Magnetic resonance imaging demonstrated a predominance of Stx1-dependent lesions in the spinal cord. Pretreatment of the animals with anti-Stx1 antiserum intravenously completely protected against both development of brain lesions and mortality.

Original language	English
Pages (from-to)	6545-6548
Number of pages	4
Journal	Infection and Immunity
Volume	69
Issue number	10
DOIs	https://doi.org/10.1128/IAI.69.10.6545-6548.2001
Publication status	Published - 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/IAI.69.10.6545-6548.2001

Cite this

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abstract = "The action of Shiga toxin (Stx) on the central nervous system was examined in rabbits. Intravenous Stx1 was 44 times more lethal than Stx2 and acted more rapidly than Stx2. However, Stx1 accumulated more slowly in the cerebrospinal fluid than did Stx2. Magnetic resonance imaging demonstrated a predominance of Stx1-dependent lesions in the spinal cord. Pretreatment of the animals with anti-Stx1 antiserum intravenously completely protected against both development of brain lesions and mortality.",

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AU - Fujii, J.

AU - Kinoshita, Y.

AU - Yutsudo, T.

AU - Taniguchi, H.

AU - Obrig, T.

AU - Yoshida, S. I.

PY - 2001

Y1 - 2001

N2 - The action of Shiga toxin (Stx) on the central nervous system was examined in rabbits. Intravenous Stx1 was 44 times more lethal than Stx2 and acted more rapidly than Stx2. However, Stx1 accumulated more slowly in the cerebrospinal fluid than did Stx2. Magnetic resonance imaging demonstrated a predominance of Stx1-dependent lesions in the spinal cord. Pretreatment of the animals with anti-Stx1 antiserum intravenously completely protected against both development of brain lesions and mortality.

AB - The action of Shiga toxin (Stx) on the central nervous system was examined in rabbits. Intravenous Stx1 was 44 times more lethal than Stx2 and acted more rapidly than Stx2. However, Stx1 accumulated more slowly in the cerebrospinal fluid than did Stx2. Magnetic resonance imaging demonstrated a predominance of Stx1-dependent lesions in the spinal cord. Pretreatment of the animals with anti-Stx1 antiserum intravenously completely protected against both development of brain lesions and mortality.

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SN - 0019-9567

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EP - 6548

JO - Infection and Immunity

JF - Infection and Immunity

IS - 10

ER -

Toxicity of Shiga toxin 1 in the central nervous system of rabbits

Abstract

All Science Journal Classification (ASJC) codes

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