Toxicity of Shiga toxin 1 in the central nervous system of rabbits

J. Fujii, Y. Kinoshita, T. Yutsudo, H. Taniguchi, T. Obrig, S. I. Yoshida

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Abstract

The action of Shiga toxin (Stx) on the central nervous system was examined in rabbits. Intravenous Stx1 was 44 times more lethal than Stx2 and acted more rapidly than Stx2. However, Stx1 accumulated more slowly in the cerebrospinal fluid than did Stx2. Magnetic resonance imaging demonstrated a predominance of Stx1-dependent lesions in the spinal cord. Pretreatment of the animals with anti-Stx1 antiserum intravenously completely protected against both development of brain lesions and mortality.

Original languageEnglish
Pages (from-to)6545-6548
Number of pages4
JournalInfection and Immunity
Volume69
Issue number10
DOIs
Publication statusPublished - Oct 2 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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  • Cite this

    Fujii, J., Kinoshita, Y., Yutsudo, T., Taniguchi, H., Obrig, T., & Yoshida, S. I. (2001). Toxicity of Shiga toxin 1 in the central nervous system of rabbits. Infection and Immunity, 69(10), 6545-6548. https://doi.org/10.1128/IAI.69.10.6545-6548.2001