Toxicological analysis of thiamylal in biological materials by gas chromatography/mass spectrometry

K. Kudo; T. Nagata; K. Kimura; R. Uehori; M. Noda

doi:10.1016/0379-0738(88)90184-3

Toxicological analysis of thiamylal in biological materials by gas chromatography/mass spectrometry

K. Kudo, T. Nagata, K. Kimura, R. Uehori, M. Noda

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A reliable and sensitive method to analyze thiamylal in biological materials was developed, using gas chromatography/mass spectrometry ( GC MS). A quantitative determination was made by use of mass fragmentography with the lower detection limit of 0.01 μg/g. Thiopental was used as the internal standard. Distribution of the drug in the blood and body tissues of rats was examined. The method was then used to detect thiamylal in tissues from an autopsied patient and concentration of this drug in the body materials was evaluated, from medico-legal aspects.

Original language	English
Pages (from-to)	193-200
Number of pages	8
Journal	Forensic Science International
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/0379-0738(88)90184-3
Publication status	Published - May 1988

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine

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10.1016/0379-0738(88)90184-3

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abstract = "A reliable and sensitive method to analyze thiamylal in biological materials was developed, using gas chromatography/mass spectrometry ( GC MS). A quantitative determination was made by use of mass fragmentography with the lower detection limit of 0.01 μg/g. Thiopental was used as the internal standard. Distribution of the drug in the blood and body tissues of rats was examined. The method was then used to detect thiamylal in tissues from an autopsied patient and concentration of this drug in the body materials was evaluated, from medico-legal aspects.",

author = "K. Kudo and T. Nagata and K. Kimura and R. Uehori and M. Noda",

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AU - Uehori, R.

AU - Noda, M.

PY - 1988/5

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AB - A reliable and sensitive method to analyze thiamylal in biological materials was developed, using gas chromatography/mass spectrometry ( GC MS). A quantitative determination was made by use of mass fragmentography with the lower detection limit of 0.01 μg/g. Thiopental was used as the internal standard. Distribution of the drug in the blood and body tissues of rats was examined. The method was then used to detect thiamylal in tissues from an autopsied patient and concentration of this drug in the body materials was evaluated, from medico-legal aspects.

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Toxicological analysis of thiamylal in biological materials by gas chromatography/mass spectrometry

Abstract

All Science Journal Classification (ASJC) codes

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