Trans-Omics

How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers

Katsuyuki Yugi, Hiroyuki Kubota, Atsushi Hatano, Shinya Kuroda

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

We propose 'trans-omic' analysis for reconstructing global biochemical networks across multiple omic layers by use of both multi-omic measurements and computational data integration. We introduce technologies for connecting multi-omic data based on prior knowledge of biochemical interactions and characterize a biochemical trans-omic network by concepts of a static and dynamic nature. We introduce case studies of metabolism-centric trans-omic studies to show how to reconstruct a biochemical trans-omic network by connecting multi-omic data and how to analyze it in terms of the static and dynamic nature. We propose a trans-ome-wide association study (trans-OWAS) connecting phenotypes with trans-omic networks that reflect both genetic and environmental factors, which can characterize several complex lifestyle diseases as breakdowns in the trans-omic system.

Original languageEnglish
Pages (from-to)276-290
Number of pages15
JournalTrends in Biotechnology
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

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Data integration
Metabolism
Life Style
Technology
Phenotype

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering

Cite this

Trans-Omics : How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers. / Yugi, Katsuyuki; Kubota, Hiroyuki; Hatano, Atsushi; Kuroda, Shinya.

In: Trends in Biotechnology, Vol. 34, No. 4, 01.04.2016, p. 276-290.

Research output: Contribution to journalReview article

Yugi, Katsuyuki ; Kubota, Hiroyuki ; Hatano, Atsushi ; Kuroda, Shinya. / Trans-Omics : How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers. In: Trends in Biotechnology. 2016 ; Vol. 34, No. 4. pp. 276-290.
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