Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers

Katsuyuki Yugi, Hiroyuki Kubota, Atsushi Hatano, Shinya Kuroda

Research output: Contribution to journalReview article

101 Citations (Scopus)

Abstract

We propose 'trans-omic' analysis for reconstructing global biochemical networks across multiple omic layers by use of both multi-omic measurements and computational data integration. We introduce technologies for connecting multi-omic data based on prior knowledge of biochemical interactions and characterize a biochemical trans-omic network by concepts of a static and dynamic nature. We introduce case studies of metabolism-centric trans-omic studies to show how to reconstruct a biochemical trans-omic network by connecting multi-omic data and how to analyze it in terms of the static and dynamic nature. We propose a trans-ome-wide association study (trans-OWAS) connecting phenotypes with trans-omic networks that reflect both genetic and environmental factors, which can characterize several complex lifestyle diseases as breakdowns in the trans-omic system.

Original languageEnglish
Pages (from-to)276-290
Number of pages15
JournalTrends in biotechnology
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering

Fingerprint Dive into the research topics of 'Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers'. Together they form a unique fingerprint.

  • Cite this