Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Izumi Ohigashi; Yu Tanaka; Kenta Kondo; Sayumi Fujimori; Hiroyuki Kondo; Amy C. Palin; Victoria Hoffmann; Mina Kozai; Yosuke Matsushita; Shinsuke Uda; Ryo Motosugi; Jun Hamazaki; Hiroyuki Kubota; Shigeo Murata; Keiji Tanaka; Toyomasa Katagiri; Hidetaka Kosako; Yousuke Takahama

doi:10.1016/j.celrep.2019.10.079

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C. Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako, Yousuke Takahama

Research Center for Transomics Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Ohigashi et al. show that the use of cyclin D1-transgenic mice allows quantitative proteomic analysis of cortical and medullary thymic epithelial cells (TECs). Results provide a trans-omics platform for further exploration of TEC biology and reveal the specific impact of the thymoproteasome on proteasome subunit composition in cortical TECs.

Original language	English
Pages (from-to)	2901-2916.e6
Journal	Cell Reports
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2019.10.079
Publication status	Published - Nov 26 2019

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.celrep.2019.10.079

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Ohigashi, I., Tanaka, Y., Kondo, K., Fujimori, S., Kondo, H., Palin, A. C., Hoffmann, V., Kozai, M., Matsushita, Y., Uda, S., Motosugi, R., Hamazaki, J., Kubota, H., Murata, S., Tanaka, K., Katagiri, T., Kosako, H., & Takahama, Y. (2019). Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells. Cell Reports, 29(9), 2901-2916.e6. https://doi.org/10.1016/j.celrep.2019.10.079

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells. / Ohigashi, Izumi; Tanaka, Yu; Kondo, Kenta; Fujimori, Sayumi; Kondo, Hiroyuki; Palin, Amy C.; Hoffmann, Victoria; Kozai, Mina; Matsushita, Yosuke; Uda, Shinsuke; Motosugi, Ryo; Hamazaki, Jun; Kubota, Hiroyuki; Murata, Shigeo; Tanaka, Keiji; Katagiri, Toyomasa; Kosako, Hidetaka; Takahama, Yousuke.

In: Cell Reports, Vol. 29, No. 9, 26.11.2019, p. 2901-2916.e6.

Research output: Contribution to journal › Article › peer-review

Ohigashi, I, Tanaka, Y, Kondo, K, Fujimori, S, Kondo, H, Palin, AC, Hoffmann, V, Kozai, M, Matsushita, Y, Uda, S, Motosugi, R, Hamazaki, J, Kubota, H, Murata, S, Tanaka, K, Katagiri, T, Kosako, H & Takahama, Y 2019, 'Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells', Cell Reports, vol. 29, no. 9, pp. 2901-2916.e6. https://doi.org/10.1016/j.celrep.2019.10.079

Ohigashi, Izumi ; Tanaka, Yu ; Kondo, Kenta ; Fujimori, Sayumi ; Kondo, Hiroyuki ; Palin, Amy C. ; Hoffmann, Victoria ; Kozai, Mina ; Matsushita, Yosuke ; Uda, Shinsuke ; Motosugi, Ryo ; Hamazaki, Jun ; Kubota, Hiroyuki ; Murata, Shigeo ; Tanaka, Keiji ; Katagiri, Toyomasa ; Kosako, Hidetaka ; Takahama, Yousuke. / Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells. In: Cell Reports. 2019 ; Vol. 29, No. 9. pp. 2901-2916.e6.

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