Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C. Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako, Yousuke Takahama

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ohigashi et al. show that the use of cyclin D1-transgenic mice allows quantitative proteomic analysis of cortical and medullary thymic epithelial cells (TECs). Results provide a trans-omics platform for further exploration of TEC biology and reveal the specific impact of the thymoproteasome on proteasome subunit composition in cortical TECs.

Original languageEnglish
Pages (from-to)2901-2916.e6
JournalCell Reports
Volume29
Issue number9
DOIs
Publication statusPublished - Nov 26 2019

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Epithelial Cells
Cytology
Cyclin D1
Proteasome Endopeptidase Complex
Proteomics
Transgenic Mice
Cell Biology
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ohigashi, I., Tanaka, Y., Kondo, K., Fujimori, S., Kondo, H., Palin, A. C., ... Takahama, Y. (2019). Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells. Cell Reports, 29(9), 2901-2916.e6. https://doi.org/10.1016/j.celrep.2019.10.079

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells. / Ohigashi, Izumi; Tanaka, Yu; Kondo, Kenta; Fujimori, Sayumi; Kondo, Hiroyuki; Palin, Amy C.; Hoffmann, Victoria; Kozai, Mina; Matsushita, Yosuke; Uda, Shinsuke; Motosugi, Ryo; Hamazaki, Jun; Kubota, Hiroyuki; Murata, Shigeo; Tanaka, Keiji; Katagiri, Toyomasa; Kosako, Hidetaka; Takahama, Yousuke.

In: Cell Reports, Vol. 29, No. 9, 26.11.2019, p. 2901-2916.e6.

Research output: Contribution to journalArticle

Ohigashi, I, Tanaka, Y, Kondo, K, Fujimori, S, Kondo, H, Palin, AC, Hoffmann, V, Kozai, M, Matsushita, Y, Uda, S, Motosugi, R, Hamazaki, J, Kubota, H, Murata, S, Tanaka, K, Katagiri, T, Kosako, H & Takahama, Y 2019, 'Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells', Cell Reports, vol. 29, no. 9, pp. 2901-2916.e6. https://doi.org/10.1016/j.celrep.2019.10.079
Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin AC et al. Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells. Cell Reports. 2019 Nov 26;29(9):2901-2916.e6. https://doi.org/10.1016/j.celrep.2019.10.079
Ohigashi, Izumi ; Tanaka, Yu ; Kondo, Kenta ; Fujimori, Sayumi ; Kondo, Hiroyuki ; Palin, Amy C. ; Hoffmann, Victoria ; Kozai, Mina ; Matsushita, Yosuke ; Uda, Shinsuke ; Motosugi, Ryo ; Hamazaki, Jun ; Kubota, Hiroyuki ; Murata, Shigeo ; Tanaka, Keiji ; Katagiri, Toyomasa ; Kosako, Hidetaka ; Takahama, Yousuke. / Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells. In: Cell Reports. 2019 ; Vol. 29, No. 9. pp. 2901-2916.e6.
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