@article{b9c25440c67d4891936105e5e06a7caa,
title = "Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells",
abstract = "Ohigashi et al. show that the use of cyclin D1-transgenic mice allows quantitative proteomic analysis of cortical and medullary thymic epithelial cells (TECs). Results provide a trans-omics platform for further exploration of TEC biology and reveal the specific impact of the thymoproteasome on proteasome subunit composition in cortical TECs.",
author = "Izumi Ohigashi and Yu Tanaka and Kenta Kondo and Sayumi Fujimori and Hiroyuki Kondo and Palin, {Amy C.} and Victoria Hoffmann and Mina Kozai and Yosuke Matsushita and Shinsuke Uda and Ryo Motosugi and Jun Hamazaki and Hiroyuki Kubota and Shigeo Murata and Keiji Tanaka and Toyomasa Katagiri and Hidetaka Kosako and Yousuke Takahama",
note = "Funding Information: We thank Drs. Dinah Singer, Alfred Singer, Richard Hodes, Avinash Bhandoola, and Jennifer Cowan for reading the manuscript. We also thank Hitomi Kyuma, Mie Sakata, Megumi Kawano, Felix Kalle-Youngoue, Susan Sharrow, and Alison Jacques for technical assistance. This work was supported by grants from MEXT-JSPS (16H02630 and 17K08884), the Takeda Science Foundation, Sumitomo Foundation, and Novartis Foundation for the Promotion of Science (I.O.); and by the Intramural Research Program of the NIH, the National Cancer Institute, and the Center for Cancer Research (Y. Takahama). I.O. and Y. Takahama conceived the study; I.O. S.M. K.T. H. Kosako, and Y. Takahama designed the study; I.O. Y. Tanaka, K.K. S.F. H. Kondo, A.C.P. V.H. M.K. Y.M. R.M. J.H. and H. Kosako performed the experiments; T.K. managed the transcriptomic analysis; H. Kosako managed the proteomic analysis; S.U. and H. Kubota managed the trans-omics analysis; and I.O. Y. Tanaka, S.M. H. Kosako, and Y. Takahama wrote the manuscript. The authors declare no conflicting interests. Funding Information: We thank Drs. Dinah Singer, Alfred Singer, Richard Hodes, Avinash Bhandoola, and Jennifer Cowan for reading the manuscript. We also thank Hitomi Kyuma, Mie Sakata, Megumi Kawano, Felix Kalle-Youngoue, Susan Sharrow, and Alison Jacques for technical assistance. This work was supported by grants from MEXT-JSPS ( 16H02630 and 17K08884 ), the Takeda Science Foundation , Sumitomo Foundation , and Novartis Foundation for the Promotion of Science (I.O.); and by the Intramural Research Program of the NIH , the National Cancer Institute , and the Center for Cancer Research (Y. Takahama). Publisher Copyright: {\textcopyright} 2019",
year = "2019",
month = nov,
day = "26",
doi = "10.1016/j.celrep.2019.10.079",
language = "English",
volume = "29",
pages = "2901--2916.e6",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "9",
}