TY - GEN
T1 - Transcranial direct current stimulation over premotor cortex modifies the excitability of the ipsilateral primary motor and somatosensory cortices
AU - Kirimoto, Hikari
AU - Ogata, Katsuya
AU - Onishi, Hideaki
AU - Oyama, Mineo
AU - Goto, Yoshinobu
AU - Tobimatsu, Shozo
PY - 2009
Y1 - 2009
N2 - Purpose: Our aim was to study whether transcranial direct current stimulation (tDCS) over premotor cortex (PM) can modify the excitability of the ipsilateral primary motor (M1) and somatosensory (S1) cortices via cortico-cortical connectivity. Methods: Ten subjects received, anodal, cathodal and sham tDCS (1mA) over left PM for 15min. PM was determined to be 2cm anterior and 3cm medial to the hotspot of right first dorsal interosseus muscle. Motor evoked potentials (MEPs) were recorded from right first dorsal interosseus (FDI) muscle with transcranial magnetic stimulation over left M1. Somatosensory evoked potentials (SEPs) to right median nerve stimulation were also recorded from left C3'. Both MEPs and SEPs were recorded before, immediately after and 15min after tDCS. Results: The amplitudes of MEPs after anodal tDCS were shown to decrease while those of SEPs tended to increase. In contrast, the effects of cathodal tDCS were opposite to those of anodal tDCS. Statistical analysis (ANOVA) revealed that a significant interaction among INTERVENTION (anodal, cathodal) x TIME (before, after, after15min) on both MEPs (p < 0.01) and SEPs (p < 0.05). Discussion: We infer that decreased MEP amplitudes resulted from inhibitory input to M1 from PM with anodal tDCS over PM, whereas the opposite effect was mediated from PM to M1 with cathodal tDCS. It is likely that changes in S1 excitability reflect the alternation of input-output modulation between M1 and S1. Conclusion: tDCS is useful for modulating the excitability of PM with which plastic functions of M1 and S1 can be assessed.
AB - Purpose: Our aim was to study whether transcranial direct current stimulation (tDCS) over premotor cortex (PM) can modify the excitability of the ipsilateral primary motor (M1) and somatosensory (S1) cortices via cortico-cortical connectivity. Methods: Ten subjects received, anodal, cathodal and sham tDCS (1mA) over left PM for 15min. PM was determined to be 2cm anterior and 3cm medial to the hotspot of right first dorsal interosseus muscle. Motor evoked potentials (MEPs) were recorded from right first dorsal interosseus (FDI) muscle with transcranial magnetic stimulation over left M1. Somatosensory evoked potentials (SEPs) to right median nerve stimulation were also recorded from left C3'. Both MEPs and SEPs were recorded before, immediately after and 15min after tDCS. Results: The amplitudes of MEPs after anodal tDCS were shown to decrease while those of SEPs tended to increase. In contrast, the effects of cathodal tDCS were opposite to those of anodal tDCS. Statistical analysis (ANOVA) revealed that a significant interaction among INTERVENTION (anodal, cathodal) x TIME (before, after, after15min) on both MEPs (p < 0.01) and SEPs (p < 0.05). Discussion: We infer that decreased MEP amplitudes resulted from inhibitory input to M1 from PM with anodal tDCS over PM, whereas the opposite effect was mediated from PM to M1 with cathodal tDCS. It is likely that changes in S1 excitability reflect the alternation of input-output modulation between M1 and S1. Conclusion: tDCS is useful for modulating the excitability of PM with which plastic functions of M1 and S1 can be assessed.
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U2 - 10.1109/ICCME.2009.4906610
DO - 10.1109/ICCME.2009.4906610
M3 - Conference contribution
AN - SCOPUS:67650676043
SN - 9781424433162
T3 - 2009 ICME International Conference on Complex Medical Engineering, CME 2009
BT - 2009 ICME International Conference on Complex Medical Engineering, CME 2009
T2 - 2009 ICME International Conference on Complex Medical Engineering, CME 2009
Y2 - 9 April 2009 through 11 April 2009
ER -