Transcranial magnetic stimulation (TMS) applied to left dorsolateral prefrontal cortex disrupts verbal working memory performance in humans

Naoyuki Osaka, Yuki Otsuka, Nobuyuki Hirose, Takashi Ikeda, Tatsuya Mima, Hidenao Fukuyama, Mariko Osaka

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Working memory refers to the temporary maintenance and processing of information and involves executive processes that manipulate the contents of the working memory. The role of the executive function in the human left dorsolateral prefrontal cortex (LDLPFC) was explored using transcranial magnetic stimulation (TMS) after confirming the LDLPFC activation using fMRI. We applied double-pulse TMS having a 100-ms inter-pulse interval to LDLPFC immediately after the subjects finished reading the sentences of the reading span test (RST) task, an efficient measure of verbal working memory, in which dual tasks that include both sentence comprehension and word maintenance are required. Using eight normal participants, we found a significant deterioration of performance, i.e., decreased number of correctly reported words, in RST due to TMS stimulation of LDLPFC. Evidence suggests that transient functional disruption of the LDLPFC impairs performance in the maintenance processing of the RST task.

Original languageEnglish
Pages (from-to)232-235
Number of pages4
JournalNeuroscience Letters
Volume418
Issue number3
DOIs
Publication statusPublished - May 18 2007
Externally publishedYes

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Transcranial Magnetic Stimulation
Prefrontal Cortex
Short-Term Memory
Reading
Maintenance
Executive Function
Automatic Data Processing
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Transcranial magnetic stimulation (TMS) applied to left dorsolateral prefrontal cortex disrupts verbal working memory performance in humans. / Osaka, Naoyuki; Otsuka, Yuki; Hirose, Nobuyuki; Ikeda, Takashi; Mima, Tatsuya; Fukuyama, Hidenao; Osaka, Mariko.

In: Neuroscience Letters, Vol. 418, No. 3, 18.05.2007, p. 232-235.

Research output: Contribution to journalArticle

Osaka, Naoyuki ; Otsuka, Yuki ; Hirose, Nobuyuki ; Ikeda, Takashi ; Mima, Tatsuya ; Fukuyama, Hidenao ; Osaka, Mariko. / Transcranial magnetic stimulation (TMS) applied to left dorsolateral prefrontal cortex disrupts verbal working memory performance in humans. In: Neuroscience Letters. 2007 ; Vol. 418, No. 3. pp. 232-235.
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