Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

Takahiro Masuda, Shosuke Iwamoto, Satsuki Mikuriya, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Makoto Tsuda, Kazuhide Inoue

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Interferon regulatory factor-8 (IRF8) plays a crucial role in the transformation of microglia to a reactive state by regulating the expression of various genes. In the present study, we show that IRF1 is required for IRF8-induced gene expression in microglia. Peripheral nerve injury induced IRF1 gene upregulation in the spinal microglia in an IRF8-dependent manner. IRF8 transduction in cultured microglia induced de novo gene expression of IRF1. Importantly, knockdown of the IRF1 gene in IRF8-transduced microglia prevented upregulation of interleukin-1β (IL-1β). Therefore, our findings suggest that expression of IL-1β is dependent on IRF1 in IRF8-expressing reactive microglia.

Original languageEnglish
Pages (from-to)216-220
Number of pages5
JournalJournal of Pharmacological Sciences
Volume128
Issue number4
DOIs
Publication statusPublished - Sep 4 2015

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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