Transcriptional regulation of CYP11A1

Ing Cherng Guo, Meng Chun Hu, Bon Chu Chung

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Steroid hormones are important physiological regulators that control our glucose and salt balance, as well as sexual characteristics. The synthesis of steroid hormones is under tight control; disturbed secretion of steroids often leads to diseases. The mechanism controlling the secretion of steroids, namely steroidogenesis, has been the focus of intensive studies. CYP11A1 controls the first and rate-limiting step of steroid biosynthesis. It is expressed in the adrenal cortex and gonads, under the control of pituitary hormones, through the cAMP-signaling pathway. The promoter of the CYP11A1 gene contains sequences that bind to transcription factor SF-1, which plays an important role in the tissue-specific and hormonally regulated expression of steroidogenic genes. Detailed transcriptional analysis documents the importance of SF-1 in activating CYP11A1 in vitro and in vivo. Other factors like c-Jun are also involved. The assembly of various transcription factors forming protein-DNA complexes appears to be the key step in CYP11A1 transcription.

Original languageEnglish
Pages (from-to)593-598
Number of pages6
JournalJournal of Biomedical Science
Volume10
Issue number6 I
DOIs
Publication statusPublished - Nov 14 2003

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Cholesterol Side-Chain Cleavage Enzyme
Steroid hormones
Steroids
Genes
Steroidogenic Factor 1
Pituitary Hormones
Hormones
Biosynthesis
Transcription
Adrenal Cortex
Gonads
Transcription Factors
Salts
Tissue
Glucose
DNA
Gene Expression
Proteins

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Guo, I. C., Hu, M. C., & Chung, B. C. (2003). Transcriptional regulation of CYP11A1. Journal of Biomedical Science, 10(6 I), 593-598. https://doi.org/10.1159/000073524

Transcriptional regulation of CYP11A1. / Guo, Ing Cherng; Hu, Meng Chun; Chung, Bon Chu.

In: Journal of Biomedical Science, Vol. 10, No. 6 I, 14.11.2003, p. 593-598.

Research output: Contribution to journalReview article

Guo, IC, Hu, MC & Chung, BC 2003, 'Transcriptional regulation of CYP11A1', Journal of Biomedical Science, vol. 10, no. 6 I, pp. 593-598. https://doi.org/10.1159/000073524
Guo, Ing Cherng ; Hu, Meng Chun ; Chung, Bon Chu. / Transcriptional regulation of CYP11A1. In: Journal of Biomedical Science. 2003 ; Vol. 10, No. 6 I. pp. 593-598.
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