Transcriptional regulation of human CYP11A1 in gonads and adrenals

Ing Cherng Guo, Meng Chun Shih, Hsin Chieh Lan, Nai Chi Hsu, Meng Chun Hu, Bon Chu Chung

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The CYP11A1 gene encodes the cholesterol side-chain cleavage enzyme, also termed cytochrome P450scc, which catalyzes the conversion of cholesterol to pregnenolone in the first step of steroid biosynthesis in mitochondria. The adrenal- and gonad-selective, hormonally and developmentally regulated expression of CYP11A1 is principally driven by its 2.3 kb promoter. Multiple trans-acting factors like SF-1, Sp1, AP-2, TReP-132, LBP-1b, LBP-9, AP-1, NF-1, and Ets control CYP11A1 transcription either through DNA-protein interaction with their specific cis-acting elements or through protein-protein interaction between each other, wherein SF-1 plays a central role in adrenals and testes. In addition to binding with its proximal and upstream motifs, SF-1 also physically interacts with TFIIB, CBP/p300, TReP-132, and c-Jun/AP-1 to specifically transmit the regulatory signals of cAMP. Other factors like Sp1 family members, AP-2, and LBP-1b/LBP-9 may be other factors that play a role in CYP11A1 transcription, particularly in placental cells. The TATA sequence could also contribute to tissue-specificity and hormonal regulation of CYP11A1 transcription. This article reviews recent studies focusing on adrenals and gonads.

Original languageEnglish
Pages (from-to)509-515
Number of pages7
JournalJournal of Biomedical Science
Volume14
Issue number4
DOIs
Publication statusPublished - Jul 1 2007

Fingerprint

Cholesterol Side-Chain Cleavage Enzyme
Gonads
Transcription Factor AP-1
Transcription
Transcription Factor TFIIB
Pregnenolone
Organ Specificity
Proteins
Mitochondria
Trans-Activators
Biosynthesis
Testis
Genes
Steroids
Cholesterol
Tissue
DNA

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Guo, I. C., Shih, M. C., Lan, H. C., Hsu, N. C., Hu, M. C., & Chung, B. C. (2007). Transcriptional regulation of human CYP11A1 in gonads and adrenals. Journal of Biomedical Science, 14(4), 509-515. https://doi.org/10.1007/s11373-007-9177-z

Transcriptional regulation of human CYP11A1 in gonads and adrenals. / Guo, Ing Cherng; Shih, Meng Chun; Lan, Hsin Chieh; Hsu, Nai Chi; Hu, Meng Chun; Chung, Bon Chu.

In: Journal of Biomedical Science, Vol. 14, No. 4, 01.07.2007, p. 509-515.

Research output: Contribution to journalArticle

Guo, IC, Shih, MC, Lan, HC, Hsu, NC, Hu, MC & Chung, BC 2007, 'Transcriptional regulation of human CYP11A1 in gonads and adrenals', Journal of Biomedical Science, vol. 14, no. 4, pp. 509-515. https://doi.org/10.1007/s11373-007-9177-z
Guo, Ing Cherng ; Shih, Meng Chun ; Lan, Hsin Chieh ; Hsu, Nai Chi ; Hu, Meng Chun ; Chung, Bon Chu. / Transcriptional regulation of human CYP11A1 in gonads and adrenals. In: Journal of Biomedical Science. 2007 ; Vol. 14, No. 4. pp. 509-515.
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