Transcutaneous immunization using nano-sized drug carriers

Momoko Kitaoka, Masahiro Goto

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Citations (Scopus)

    Abstract

    Growing knowledge about the immune system in the skin and recent advances in the preparation of nano-sized particles have encouraged research into the induction of an adaptive immune response via the trans-cutaneous route. Because the skin is abundant in dendritic cell subsets, vaccine administration through the transcutaneous route has promise for simple and efficient immunization and immunotherapy methods, which would provide a welcome alternative to the conventional injection technique. Strategies using a nanoparticle-based protein delivery into the skin depend on the types of nanoparticles, such as soft vesicular nanoparticles, hard inorganic and polymer nanoparticles, and surfactant-coated solid-in-oil nanoparticles. Here, we discuss the skin structure and the immune system in the skin, as well as the types of nanoparticles, routes of administration, and effects of adjuvants. In addition, a detailed description of the preparation and characteristics of solid-in-oil nanoparticles is provided for the future development of an efficient transcutaneous immunization system.

    Original languageEnglish
    Title of host publicationMethods in Pharmacology and Toxicology
    PublisherHumana Press Inc.
    Pages349-367
    Number of pages19
    Volume39
    DOIs
    Publication statusPublished - 2016

    Publication series

    NameMethods in Pharmacology and Toxicology
    Volume39
    ISSN (Print)1557-2153
    ISSN (Electronic)1940-6053

    All Science Journal Classification (ASJC) codes

    • Molecular Medicine
    • Pharmacology, Toxicology and Pharmaceutics(all)
    • Pharmacology (medical)

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