Abstract
Growing knowledge about the immune system in the skin and recent advances in the preparation of nano-sized particles have encouraged research into the induction of an adaptive immune response via the trans-cutaneous route. Because the skin is abundant in dendritic cell subsets, vaccine administration through the transcutaneous route has promise for simple and efficient immunization and immunotherapy methods, which would provide a welcome alternative to the conventional injection technique. Strategies using a nanoparticle-based protein delivery into the skin depend on the types of nanoparticles, such as soft vesicular nanoparticles, hard inorganic and polymer nanoparticles, and surfactant-coated solid-in-oil nanoparticles. Here, we discuss the skin structure and the immune system in the skin, as well as the types of nanoparticles, routes of administration, and effects of adjuvants. In addition, a detailed description of the preparation and characteristics of solid-in-oil nanoparticles is provided for the future development of an efficient transcutaneous immunization system.
| Original language | English |
|---|---|
| Title of host publication | Methods in Pharmacology and Toxicology |
| Publisher | Humana Press Inc. |
| Pages | 349-367 |
| Number of pages | 19 |
| Volume | 39 |
| DOIs | |
| Publication status | Published - 2016 |
Publication series
| Name | Methods in Pharmacology and Toxicology |
|---|---|
| Volume | 39 |
| ISSN (Print) | 1557-2153 |
| ISSN (Electronic) | 1940-6053 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology (medical)
Cite this
Transcutaneous immunization using nano-sized drug carriers. / Kitaoka, Momoko; Goto, Masahiro.
Methods in Pharmacology and Toxicology. Vol. 39 Humana Press Inc., 2016. p. 349-367 (Methods in Pharmacology and Toxicology; Vol. 39).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Transcutaneous immunization using nano-sized drug carriers
AU - Kitaoka, Momoko
AU - Goto, Masahiro
PY - 2016
Y1 - 2016
N2 - Growing knowledge about the immune system in the skin and recent advances in the preparation of nano-sized particles have encouraged research into the induction of an adaptive immune response via the trans-cutaneous route. Because the skin is abundant in dendritic cell subsets, vaccine administration through the transcutaneous route has promise for simple and efficient immunization and immunotherapy methods, which would provide a welcome alternative to the conventional injection technique. Strategies using a nanoparticle-based protein delivery into the skin depend on the types of nanoparticles, such as soft vesicular nanoparticles, hard inorganic and polymer nanoparticles, and surfactant-coated solid-in-oil nanoparticles. Here, we discuss the skin structure and the immune system in the skin, as well as the types of nanoparticles, routes of administration, and effects of adjuvants. In addition, a detailed description of the preparation and characteristics of solid-in-oil nanoparticles is provided for the future development of an efficient transcutaneous immunization system.
AB - Growing knowledge about the immune system in the skin and recent advances in the preparation of nano-sized particles have encouraged research into the induction of an adaptive immune response via the trans-cutaneous route. Because the skin is abundant in dendritic cell subsets, vaccine administration through the transcutaneous route has promise for simple and efficient immunization and immunotherapy methods, which would provide a welcome alternative to the conventional injection technique. Strategies using a nanoparticle-based protein delivery into the skin depend on the types of nanoparticles, such as soft vesicular nanoparticles, hard inorganic and polymer nanoparticles, and surfactant-coated solid-in-oil nanoparticles. Here, we discuss the skin structure and the immune system in the skin, as well as the types of nanoparticles, routes of administration, and effects of adjuvants. In addition, a detailed description of the preparation and characteristics of solid-in-oil nanoparticles is provided for the future development of an efficient transcutaneous immunization system.
UR - http://www.scopus.com/inward/record.url?scp=84946781963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946781963&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-3121-7_18
DO - 10.1007/978-1-4939-3121-7_18
M3 - Chapter
AN - SCOPUS:84946781963
VL - 39
T3 - Methods in Pharmacology and Toxicology
SP - 349
EP - 367
BT - Methods in Pharmacology and Toxicology
PB - Humana Press Inc.
ER -