Transcutaneous immunization using nano-sized drug carriers

Momoko Kitaoka, Masahiro Goto

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Growing knowledge about the immune system in the skin and recent advances in the preparation of nano-sized particles have encouraged research into the induction of an adaptive immune response via the trans-cutaneous route. Because the skin is abundant in dendritic cell subsets, vaccine administration through the transcutaneous route has promise for simple and efficient immunization and immunotherapy methods, which would provide a welcome alternative to the conventional injection technique. Strategies using a nanoparticle-based protein delivery into the skin depend on the types of nanoparticles, such as soft vesicular nanoparticles, hard inorganic and polymer nanoparticles, and surfactant-coated solid-in-oil nanoparticles. Here, we discuss the skin structure and the immune system in the skin, as well as the types of nanoparticles, routes of administration, and effects of adjuvants. In addition, a detailed description of the preparation and characteristics of solid-in-oil nanoparticles is provided for the future development of an efficient transcutaneous immunization system.

Original languageEnglish
Title of host publicationMethods in Pharmacology and Toxicology
PublisherHumana Press Inc.
Pages349-367
Number of pages19
Volume39
DOIs
Publication statusPublished - 2016

Publication series

NameMethods in Pharmacology and Toxicology
Volume39
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053

Fingerprint

Drug Carriers
Nanoparticles
Immunization
Skin
Immune System
Oils
Cutaneous Administration
Adaptive Immunity
Surface-Active Agents
Immunotherapy
Dendritic Cells
Polymers
Vaccines
Injections
Research

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Kitaoka, M., & Goto, M. (2016). Transcutaneous immunization using nano-sized drug carriers. In Methods in Pharmacology and Toxicology (Vol. 39, pp. 349-367). (Methods in Pharmacology and Toxicology; Vol. 39). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-3121-7_18

Transcutaneous immunization using nano-sized drug carriers. / Kitaoka, Momoko; Goto, Masahiro.

Methods in Pharmacology and Toxicology. Vol. 39 Humana Press Inc., 2016. p. 349-367 (Methods in Pharmacology and Toxicology; Vol. 39).

Research output: Chapter in Book/Report/Conference proceedingChapter

Kitaoka, M & Goto, M 2016, Transcutaneous immunization using nano-sized drug carriers. in Methods in Pharmacology and Toxicology. vol. 39, Methods in Pharmacology and Toxicology, vol. 39, Humana Press Inc., pp. 349-367. https://doi.org/10.1007/978-1-4939-3121-7_18
Kitaoka M, Goto M. Transcutaneous immunization using nano-sized drug carriers. In Methods in Pharmacology and Toxicology. Vol. 39. Humana Press Inc. 2016. p. 349-367. (Methods in Pharmacology and Toxicology). https://doi.org/10.1007/978-1-4939-3121-7_18
Kitaoka, Momoko ; Goto, Masahiro. / Transcutaneous immunization using nano-sized drug carriers. Methods in Pharmacology and Toxicology. Vol. 39 Humana Press Inc., 2016. pp. 349-367 (Methods in Pharmacology and Toxicology).
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