Transdermal delivery of adriamycin to transplanted ehrlich ascites tumor in mice

Masataka Shiozuka, Yoshiaki Nonomura, Ryoichi Matsuda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

There is considerable interest in the skin as a site of anti-cancer drug application. Nevertheless, the skin poses a formidable barrier to drug penetration, thereby limiting topical and transdermal bioavailability. However, we previously showed that a thioglycolate-based depilatory agent increases the drug permeability of mouse skin. In the present report, we investigated the skin permeability and efficacy of the anti-cancer drug adriamycin increased when administered transdermally to mice in combination with a thioglycolate-based depilatory agent. Adriamycin in combination with depilatory treatment reduced Ehrlich tumor growth in hairless mice about the weight and size of harvested tumors. In addition, our delivery method for adriamycin increased the therapeutic effectiveness of this agent by decreasing toxicity. Moreover, measurement of adriamycin autofluorescence revealed that topically applied adriamycin penetrate the dermis after depilatory agent treatment. These results indicate that the transdermal delivery of anti-cancer drugs is feasible by handy pretreatment of the skin with a thioglycolate-based depilatory agent.

Original languageEnglish
Pages (from-to)385-391
Number of pages7
JournalPharmaceutics
Volume5
Issue number3
DOIs
Publication statusPublished - Jul 11 2013

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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