Transfer of resistance to primary infection of Listeria monocytogenes and early induction of delayed hypersensitivity by sera from L. monocytogenes-infected mice

A. Yamada, K. Himeno, Seiji Nakamura, I. Kawamura, K. Nomoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We found a new phenomenon which differs from previous reports on experimental listeriosis, that is, failure of passive transfer of serum from Listeria monocytogenes-infected mice to convey resistance to the bacterium. Transfer of immune serum from L. monocytogenes-infected mice markedly augmented resistance to the bacterium, and mechanisms of the transfer of L. monocytogenes-immune serum were investigated. Transfer of immune serum prevented L. monocytogenes lethality. This effect of the immune serum was transferred dose dependently. Augmentation of resistance of L. monocytogenes also appeared to elimination of bacteria from the spleen. The growth of bacteria within 2 days in the spleen was not inhibited. Transfer of the immune serum augmented and accelerated induction of a delayed footpad reaction. Delayed hypersensitivity-dependent accumulation of mononuclear cells, detected by focus formation reaction in the liver, was also augmented. In contrast, polymorphonuclear cell accumulation in the liver was suppressed. Development of delayed hypersensitivity reactions was correlated with the elimination of bacteria in the spleen. These effects of the immune serum were expressed antigen specifically; however, the effector molecule(s) in the immune serum differs from immunoglobulin molecules.

Original languageEnglish
Pages (from-to)3078-3084
Number of pages7
JournalInfection and Immunity
Volume55
Issue number12
Publication statusPublished - Dec 1 1987

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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