Transformation from multi- To single-lamellar vesicle by addition of a cationic lipid to 1,2-dilauroyl-sn-glycero-3-phosphocholine explored with SAXS and TEM

Genki Kubo, Shunsuke Sakamoto, Shota Fujii, Yusuke Sanada, Takuo Yasunaga, Atsushi Takahara, Kazuo Sakurai

Research output: Contribution to journalArticle

Abstract

1,2-Dilauroyl-sn-glycero-3-phosphocholine (DLPC) is one of the major lipids constituting cellular membranes. When DLPC itself is dispersed in aqueous solutions, multilamellar vesicles are formed, although the cellular membranes are made of single bilayers. We found that the addition of a calix[4]arene derivative (CaL[4]C3) bearing four amine groups as the headgroup to the DLPC multilamellar vesicle induced the structural transformation to a single-lamellar vesicle, by use of small-angle X-ray scattering and electron microscopy, indicating that the highly condensed ionic groups of CaL[4]C3 are useful to control membrane morphology.

Original languageEnglish
Pages (from-to)1785-1787
Number of pages3
JournalChemistry Letters
Volume43
Issue number11
DOIs
Publication statusPublished - 2014

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Transmission electron microscopy
Membranes
Lipids
Bearings (structural)
X ray scattering
Electron microscopy
Amines
Derivatives
1,2-dilauroylphosphatidylcholine
calix(4)arene

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Transformation from multi- To single-lamellar vesicle by addition of a cationic lipid to 1,2-dilauroyl-sn-glycero-3-phosphocholine explored with SAXS and TEM. / Kubo, Genki; Sakamoto, Shunsuke; Fujii, Shota; Sanada, Yusuke; Yasunaga, Takuo; Takahara, Atsushi; Sakurai, Kazuo.

In: Chemistry Letters, Vol. 43, No. 11, 2014, p. 1785-1787.

Research output: Contribution to journalArticle

Kubo, Genki ; Sakamoto, Shunsuke ; Fujii, Shota ; Sanada, Yusuke ; Yasunaga, Takuo ; Takahara, Atsushi ; Sakurai, Kazuo. / Transformation from multi- To single-lamellar vesicle by addition of a cationic lipid to 1,2-dilauroyl-sn-glycero-3-phosphocholine explored with SAXS and TEM. In: Chemistry Letters. 2014 ; Vol. 43, No. 11. pp. 1785-1787.
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AU - Yasunaga, Takuo

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