Transglutaminase in Invertebrates

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

In mammals, transglutaminases play roles in a variety of essential functions, including blood coagulation, skin formation, and signal transduction, by catalyzing the isopeptide bond formation between Lys and Gln residues to form e-(γ-glutamyl) lysine bonds between appropriate substrates. Similarly, in invertebrates, such as the horseshoe crab Tachypleus tridentatus, the crayfish Pacifastacus leniusculus, and the fruit fly Drosophila melanogaster, transglutaminase is conserved and exhibits pleiotropic functions. In 1993, the first report of a nucleotide sequence of the intracellular transglutaminase in T. tridentatus was made. Today, the functions of invertebrate transglutaminases are widely investigated using biochemical and genetic techniques. Here we review the existing knowledge of invertebrate transglutaminases with an emphasis on the importance of various physiological properties in innate immune reactions.

Original languageEnglish
Title of host publicationTransglutaminases
Subtitle of host publicationMultiple Functional Modifiers and Targets for New Drug Discovery
PublisherSpringer Japan
Pages117-127
Number of pages11
ISBN (Electronic)9784431558255
ISBN (Print)9784431558231
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Transglutaminases
Invertebrates
Horseshoe Crabs
Antigen-antibody reactions
Genetic Techniques
Astacoidea
Signal transduction
Mammals
Blood Coagulation
Fruits
Coagulation
Drosophila melanogaster
Diptera
Lysine
Molecular Biology
Signal Transduction
Fruit
Skin
Blood
Nucleotides

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Shibata, T., & Kawabata, S-I. (2016). Transglutaminase in Invertebrates. In Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery (pp. 117-127). Springer Japan. https://doi.org/10.1007/978-4-431-55825-5_5

Transglutaminase in Invertebrates. / Shibata, Toshio; Kawabata, Shun-Ichiro.

Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan, 2016. p. 117-127.

Research output: Chapter in Book/Report/Conference proceedingChapter

Shibata, T & Kawabata, S-I 2016, Transglutaminase in Invertebrates. in Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan, pp. 117-127. https://doi.org/10.1007/978-4-431-55825-5_5
Shibata T, Kawabata S-I. Transglutaminase in Invertebrates. In Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan. 2016. p. 117-127 https://doi.org/10.1007/978-4-431-55825-5_5
Shibata, Toshio ; Kawabata, Shun-Ichiro. / Transglutaminase in Invertebrates. Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan, 2016. pp. 117-127
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