Transglutaminase in Invertebrates

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

In mammals, transglutaminases play roles in a variety of essential functions, including blood coagulation, skin formation, and signal transduction, by catalyzing the isopeptide bond formation between Lys and Gln residues to form e-(γ-glutamyl) lysine bonds between appropriate substrates. Similarly, in invertebrates, such as the horseshoe crab Tachypleus tridentatus, the crayfish Pacifastacus leniusculus, and the fruit fly Drosophila melanogaster, transglutaminase is conserved and exhibits pleiotropic functions. In 1993, the first report of a nucleotide sequence of the intracellular transglutaminase in T. tridentatus was made. Today, the functions of invertebrate transglutaminases are widely investigated using biochemical and genetic techniques. Here we review the existing knowledge of invertebrate transglutaminases with an emphasis on the importance of various physiological properties in innate immune reactions.

Original languageEnglish
Title of host publicationTransglutaminases
Subtitle of host publicationMultiple Functional Modifiers and Targets for New Drug Discovery
PublisherSpringer Japan
Pages117-127
Number of pages11
ISBN (Electronic)9784431558255
ISBN (Print)9784431558231
DOIs
Publication statusPublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Transglutaminase in Invertebrates'. Together they form a unique fingerprint.

Cite this