Transient dysautonomia in an acute phase of encephalopathy with biphasic seizures and late reduced diffusion

Yuko Ichimiya, Noriyuki Kaku, Yasunari Sakai, Fumiya Yamashita, Wakato Matsuoka, Mamoru Muraoka, Satoshi Akamine, Soichi Mizuguchi, Michiko Torio, Yoshitomo Motomura, Yuichiro Hirata, Yoshito Ishizaki, Masafumi Sanefuji, Hiroyuki Torisu, Hidetoshi Takada, Yoshihiko Maehara, Shouichi Ohga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Paroxysmal sympathetic hyperactivity (PSH) is a dysautonomic condition that is associated with various types of acquired brain injuries. Traumatic brain lesions have been documented as the leading cause of PSH. However, detailed clinical features of pediatric PSH caused by intrinsic brain lesions remain to be elusive. We present a 3-year-old boy, who had been diagnosed as having cerebral palsy, developmental delay and epilepsy after perinatal hypoxia-induced brain injury. He developed status epilepticus with fever on the third day of respiratory infection. Whereas the seizure was terminated by systemic infusion of midazolam, consciousness remained disturbed for the next 48 h. Serial magnetic resonance imaging studies revealed that acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) evolved on 3 days after the seizure. Therapeutic hypothermia was immediately introduced, however, the brain lesion extended to the whole subcortical white matters on day 8. The intermittent bilateral dilation of pupils with increased blood pressure and tachycardia were observed until day 12. Real-time monitoring of electroencephalograms ruled out the recurrent attacks of seizures. The abnormal signs of autonomic nervous system gradually ceased and never relapsed after recovery from the hypothermia. PSH or a transient condition of dysautonomia may emerge and persist during the acute phase of AESD.

Original languageEnglish
Pages (from-to)621-624
Number of pages4
JournalBrain and Development
Volume39
Issue number7
DOIs
Publication statusPublished - Aug 2017

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Primary Dysautonomias
Brain Diseases
Seizures
Brain Injuries
Brain
Induced Hypothermia
Status Epilepticus
Midazolam
Autonomic Nervous System
Cerebral Palsy
Pupil
Hypothermia
Consciousness
Tachycardia
Respiratory Tract Infections
Dilatation
Electroencephalography
Epilepsy
Fever
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Transient dysautonomia in an acute phase of encephalopathy with biphasic seizures and late reduced diffusion. / Ichimiya, Yuko; Kaku, Noriyuki; Sakai, Yasunari; Yamashita, Fumiya; Matsuoka, Wakato; Muraoka, Mamoru; Akamine, Satoshi; Mizuguchi, Soichi; Torio, Michiko; Motomura, Yoshitomo; Hirata, Yuichiro; Ishizaki, Yoshito; Sanefuji, Masafumi; Torisu, Hiroyuki; Takada, Hidetoshi; Maehara, Yoshihiko; Ohga, Shouichi.

In: Brain and Development, Vol. 39, No. 7, 08.2017, p. 621-624.

Research output: Contribution to journalArticle

Ichimiya, Yuko ; Kaku, Noriyuki ; Sakai, Yasunari ; Yamashita, Fumiya ; Matsuoka, Wakato ; Muraoka, Mamoru ; Akamine, Satoshi ; Mizuguchi, Soichi ; Torio, Michiko ; Motomura, Yoshitomo ; Hirata, Yuichiro ; Ishizaki, Yoshito ; Sanefuji, Masafumi ; Torisu, Hiroyuki ; Takada, Hidetoshi ; Maehara, Yoshihiko ; Ohga, Shouichi. / Transient dysautonomia in an acute phase of encephalopathy with biphasic seizures and late reduced diffusion. In: Brain and Development. 2017 ; Vol. 39, No. 7. pp. 621-624.
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