Transient elastography for patients with chronic hepatitis B and C virus infection

Non-invasive, quantitative assessment of liver fibrosis

Eiichi Ogawa, Norihiro Furusyo, Kazuhiro Toyoda, Hiroaki Takeoka, Shigeru Otaguro, Maki Hamada, Murata Masayuki, Yasunori Sawayama, Jun Hayashi

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Aim/Methods: The aim of the present study was to compare the diagnostic performance of transient elastography (FibroScan) with that of serum fibrosis markers and stages of hepatic fibrosis by biopsy in 68 patients with chronic hepatitis B virus (HBV) and in 161 patients with hepatitis C virus (HCV) infection. Results: The serum levels of hyaluronic acid (r = 0.601) and type IV collagen (r = 0.663) significantly positively associated with the FibroScan values (all P < 0.05). Classified by fibrosis stages, the median values of FibroScan were 3.5 kPa for F0, 6.4 kPa for F1, 9.5 kPa for F2, 11.4 kPa for F3, and 15.4 kPa forF4 in patients with chronic HBV infection, and were 6.3 kPa for F0, 6.7 kPa for F1, 9.1 kPa for F2, 13.7 kPa for F3, and 26.4 kPa for F4 in those with chronic HCV infection. The values were significantly correlated with fibrosis stage for both (HBV, r = 0.559, P = 0.0093, and HCV, r = 0.686, P < 0.0001). Conclusion: These results suggest that FibroScan is an efficient and simple method for evaluating liver fibrosis in patients with chronic infection, both for HBV and HCV.

Original languageEnglish
Pages (from-to)1002-1010
Number of pages9
JournalHepatology Research
Volume37
Issue number12
DOIs
Publication statusPublished - Dec 2007

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Elasticity Imaging Techniques
Chronic Hepatitis B
Chronic Hepatitis C
Virus Diseases
Hepatitis B virus
Hepacivirus
Liver Cirrhosis
Fibrosis
Collagen Type IV
Hyaluronic Acid
Biomarkers
Biopsy
Liver
Infection
Serum

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

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Transient elastography for patients with chronic hepatitis B and C virus infection : Non-invasive, quantitative assessment of liver fibrosis. / Ogawa, Eiichi; Furusyo, Norihiro; Toyoda, Kazuhiro; Takeoka, Hiroaki; Otaguro, Shigeru; Hamada, Maki; Masayuki, Murata; Sawayama, Yasunori; Hayashi, Jun.

In: Hepatology Research, Vol. 37, No. 12, 12.2007, p. 1002-1010.

Research output: Contribution to journalArticle

Ogawa, Eiichi ; Furusyo, Norihiro ; Toyoda, Kazuhiro ; Takeoka, Hiroaki ; Otaguro, Shigeru ; Hamada, Maki ; Masayuki, Murata ; Sawayama, Yasunori ; Hayashi, Jun. / Transient elastography for patients with chronic hepatitis B and C virus infection : Non-invasive, quantitative assessment of liver fibrosis. In: Hepatology Research. 2007 ; Vol. 37, No. 12. pp. 1002-1010.
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