Transient Elastography for the prediction of oxaliplatin-associated liver injury in colon cancer patients: A preliminary analysis

Eiji Oki, Yoshihiro Kakeji, Akinobu Taketomi, Yoichi Yamashita, Kippei Ohgaki, Noboru Harada, Tomohiro Iguchi, Kotaro Shibahara, Noriaki Sadanaga, Masaru Morita, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Objective: The prognosis of advanced colon cancer has improved significantly over the last decade since new chemotherapy regimens including oxaliplatin have been developed. However, oxaliplatin-induced liver injury and characterized hepatic hemostatic status can occur after chemotherapy. The assessment of this type of liver injury is often difficult. Methods: Elastography (Fibroscan™) was used to evaluate liver injury in five cases before and after 5-FU, leucovorin, and oxaliplatin combination (FOLFOX) treatment. Results: A clear change was observed in the stiffness of liver after chemotherapy within 48 h, and the hepatic stiffness was normalized in most cases after 2 weeks. Among the five patients, one patient showed aberrant elevation after a FOLFOX treatment, and the patient showed liver injury pathologically. Conclusion: Elastography is a good tool for evaluating hepatic injury after FOLFOX treatment.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalJournal of Gastrointestinal Cancer
Volume39
Issue number1-4
DOIs
Publication statusPublished - Mar 2008

All Science Journal Classification (ASJC) codes

  • Oncology
  • Gastroenterology

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