Translational research on neuropsychiatrie disorders: Focusing on microglia hypothesis

Takahiro A. Kato, Masahiro Ohgidani, Shigenobu Kanba

Research output: Contribution to journalArticle

Abstract

Microglia - immune cells in the brain - have recently been highlighted to understand the pathophysiology of psychiatric disorders such as schizophrenia, depression, and autism. In this review paper, we introduce the microglia hypothesis for psychiatric disorders. In addition, we introduce our novel translational research approach to psychiatric disorders using microglia-like (iMG) cells directly induced from human blood, these iMG cells can be produced from peripheral monocytes within two weeks using two cytokines: granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-34 (IL-34).

Original languageEnglish
Pages (from-to)1007-1015
Number of pages9
JournalBrain and Nerve
Volume69
Issue number9
Publication statusPublished - Sep 2017

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All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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