Transvenous vagal nerve stimulation (VNS) in acute myocardial infarction (AMI) reduces the infarct size and improves long term cardiac function

Kana Fujii, Takahiro Arimura, Keita Saku, Takamori Kakino, Takuya Akashi, Tomomi Ide, Takuya Kishi, Kenji Sunagawa

Research output: Contribution to journalComment/debate

Abstract

VNS is known to have an anti-infarct effect. However, the technical difficulty associated with VNS precludes its application under clinical settings of AMI. We developed a novel technique where we stimulate the vagal nerves transvenously, and evaluated how the VNS affects the infarction size and cardiac function in the long term. We ligated the left anterior descending coronary artery for 3 hours, then reperfused. For transvenous VNS, we performed the field electrical stimulation at the superior vena cava. One month after the ischemia-reperfusion, we compared the infarct size and cardiac function with/without VNS. Transvenous VNS significantly decreased the infarction size by more than 80% (1.1±1.2 vs. 7.8±1.2cm2, p<0.05), doubled left ventricular systolic elastance (13.2±0.6 vs. 6.5±1.7 mmHg/ml, p<0.05), and decreased NT-pro BNP (843±256 vs. 3667±1637 pmol/ml, p<0.05). In conclusion, transvenous VNS in AMI markedly reduces the infarct size and improves cardiac function in the long term.

Original languageEnglish
Pages (from-to)O-86-O-87
JournalTransactions of Japanese Society for Medical and Biological Engineering
Volume52
DOIs
Publication statusPublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Transvenous vagal nerve stimulation (VNS) in acute myocardial infarction (AMI) reduces the infarct size and improves long term cardiac function. / Fujii, Kana; Arimura, Takahiro; Saku, Keita; Kakino, Takamori; Akashi, Takuya; Ide, Tomomi; Kishi, Takuya; Sunagawa, Kenji.

In: Transactions of Japanese Society for Medical and Biological Engineering, Vol. 52, 01.01.2014, p. O-86-O-87.

Research output: Contribution to journalComment/debate

Fujii, Kana ; Arimura, Takahiro ; Saku, Keita ; Kakino, Takamori ; Akashi, Takuya ; Ide, Tomomi ; Kishi, Takuya ; Sunagawa, Kenji. / Transvenous vagal nerve stimulation (VNS) in acute myocardial infarction (AMI) reduces the infarct size and improves long term cardiac function. In: Transactions of Japanese Society for Medical and Biological Engineering. 2014 ; Vol. 52. pp. O-86-O-87.
@article{c3bf35deb5be42f7bc1c5a56423b0152,
title = "Transvenous vagal nerve stimulation (VNS) in acute myocardial infarction (AMI) reduces the infarct size and improves long term cardiac function",
abstract = "VNS is known to have an anti-infarct effect. However, the technical difficulty associated with VNS precludes its application under clinical settings of AMI. We developed a novel technique where we stimulate the vagal nerves transvenously, and evaluated how the VNS affects the infarction size and cardiac function in the long term. We ligated the left anterior descending coronary artery for 3 hours, then reperfused. For transvenous VNS, we performed the field electrical stimulation at the superior vena cava. One month after the ischemia-reperfusion, we compared the infarct size and cardiac function with/without VNS. Transvenous VNS significantly decreased the infarction size by more than 80{\%} (1.1±1.2 vs. 7.8±1.2cm2, p<0.05), doubled left ventricular systolic elastance (13.2±0.6 vs. 6.5±1.7 mmHg/ml, p<0.05), and decreased NT-pro BNP (843±256 vs. 3667±1637 pmol/ml, p<0.05). In conclusion, transvenous VNS in AMI markedly reduces the infarct size and improves cardiac function in the long term.",
author = "Kana Fujii and Takahiro Arimura and Keita Saku and Takamori Kakino and Takuya Akashi and Tomomi Ide and Takuya Kishi and Kenji Sunagawa",
year = "2014",
month = "1",
day = "1",
doi = "10.11239/jsmbe.52.O-86",
language = "English",
volume = "52",
pages = "O--86--O--87",
journal = "BME = Bio medical engineering / henshu, Nihon ME Gakkai",
issn = "1347-443X",
publisher = "Japanese Society for Medical and Biological Engineering",

}

TY - JOUR

T1 - Transvenous vagal nerve stimulation (VNS) in acute myocardial infarction (AMI) reduces the infarct size and improves long term cardiac function

AU - Fujii, Kana

AU - Arimura, Takahiro

AU - Saku, Keita

AU - Kakino, Takamori

AU - Akashi, Takuya

AU - Ide, Tomomi

AU - Kishi, Takuya

AU - Sunagawa, Kenji

PY - 2014/1/1

Y1 - 2014/1/1

N2 - VNS is known to have an anti-infarct effect. However, the technical difficulty associated with VNS precludes its application under clinical settings of AMI. We developed a novel technique where we stimulate the vagal nerves transvenously, and evaluated how the VNS affects the infarction size and cardiac function in the long term. We ligated the left anterior descending coronary artery for 3 hours, then reperfused. For transvenous VNS, we performed the field electrical stimulation at the superior vena cava. One month after the ischemia-reperfusion, we compared the infarct size and cardiac function with/without VNS. Transvenous VNS significantly decreased the infarction size by more than 80% (1.1±1.2 vs. 7.8±1.2cm2, p<0.05), doubled left ventricular systolic elastance (13.2±0.6 vs. 6.5±1.7 mmHg/ml, p<0.05), and decreased NT-pro BNP (843±256 vs. 3667±1637 pmol/ml, p<0.05). In conclusion, transvenous VNS in AMI markedly reduces the infarct size and improves cardiac function in the long term.

AB - VNS is known to have an anti-infarct effect. However, the technical difficulty associated with VNS precludes its application under clinical settings of AMI. We developed a novel technique where we stimulate the vagal nerves transvenously, and evaluated how the VNS affects the infarction size and cardiac function in the long term. We ligated the left anterior descending coronary artery for 3 hours, then reperfused. For transvenous VNS, we performed the field electrical stimulation at the superior vena cava. One month after the ischemia-reperfusion, we compared the infarct size and cardiac function with/without VNS. Transvenous VNS significantly decreased the infarction size by more than 80% (1.1±1.2 vs. 7.8±1.2cm2, p<0.05), doubled left ventricular systolic elastance (13.2±0.6 vs. 6.5±1.7 mmHg/ml, p<0.05), and decreased NT-pro BNP (843±256 vs. 3667±1637 pmol/ml, p<0.05). In conclusion, transvenous VNS in AMI markedly reduces the infarct size and improves cardiac function in the long term.

UR - http://www.scopus.com/inward/record.url?scp=84939460012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939460012&partnerID=8YFLogxK

U2 - 10.11239/jsmbe.52.O-86

DO - 10.11239/jsmbe.52.O-86

M3 - Comment/debate

AN - SCOPUS:84939460012

VL - 52

SP - O-86-O-87

JO - BME = Bio medical engineering / henshu, Nihon ME Gakkai

JF - BME = Bio medical engineering / henshu, Nihon ME Gakkai

SN - 1347-443X

ER -