Traumatic neuroma of the lower lip with intraepithelial nerve fibers

Akari Tashiro, Shinichi Imafuku, Masutaka Furue

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 42-year-old man had noticed a small tender papule on his lower lip, and the papule clinically became unnoticeable after cryosurgery. He visited our clinic because the lesion recurred up to the original size after 9 months. On examination, a linear scar and a papule, 4 mm in diameter, were observed on the mucosal lower lip. The papule was resected and histopathologically showed proliferation of nerve fibers in irregular and tortuous fascicles, thus establishing the diagnosis of traumatic neuroma. Immunohistochemical staining by antineuron-specific enolase (NSE) antibody showed proliferation of axons in the upper lamina propria and even in the mucosal epithelium overlying the tumor. Traumatic neuroma of the lower lip is very rare, and a literature search showed only one reported case. Intraepithelial proliferation of axons may be one of the characteristics of mucosal traumatic neuroma.

Original languageEnglish
Pages (from-to)320-323
Number of pages4
JournalJournal of Cutaneous Pathology
Volume35
Issue number3
DOIs
Publication statusPublished - Mar 1 2008

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Neuroma
Lip
Nerve Fibers
Axons
Cryosurgery
Phosphopyruvate Hydratase
Cicatrix
Mucous Membrane
Epithelium
Staining and Labeling
Antibodies
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

Traumatic neuroma of the lower lip with intraepithelial nerve fibers. / Tashiro, Akari; Imafuku, Shinichi; Furue, Masutaka.

In: Journal of Cutaneous Pathology, Vol. 35, No. 3, 01.03.2008, p. 320-323.

Research output: Contribution to journalArticle

Tashiro, Akari ; Imafuku, Shinichi ; Furue, Masutaka. / Traumatic neuroma of the lower lip with intraepithelial nerve fibers. In: Journal of Cutaneous Pathology. 2008 ; Vol. 35, No. 3. pp. 320-323.
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