Treatment outcome of radiotherapy for localized primary ocular adnexal MALT lymphoma - Prognostic effect of the AJCC tumor-node-metastasis clinical staging system

Saiji Ohga, Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Toshihiro Yamaguchi, Tadamasa Yoshitake, Kotaro Terashima, Kaori Asai, Keiji Matsumoto, Hiroshi Honda

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Aim: To analyze the treatment outcome of radiotherapy for localized primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (POAML) and evaluate the prognostic effect of the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) clinical staging system for POAML. Patients and Methods: Seventy-three patients with Ann Arbor stage IE POAML who were treated with radiotherapy alone were analyzed. T-Factor based on the AJCC staging system was T1 in 28, T2 in 33 and T3 in 12 patients. Results: Out of nine patients with relapse, six had distant and three had contralateral ocular adnexal relapse. One patient died of lymphoma progression. The 5-year local control and progression-free survival (PFS) rates were 100% and 81.5%, respectively. T-Factor was not significantly associated with PFS. Conclusion: Radiotherapy achieved excellent local control and survival rates for stage IE POAML. The AJCC TNM clinical staging system was not significantly predictive for PFS of stage IE POAML.

Original languageEnglish
Pages (from-to)3591-3597
Number of pages7
JournalAnticancer research
Issue number6
Publication statusPublished - Jun 1 2015


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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