Trends in autopsy-verified dementia prevalence over 29 years of the Hisayama study

Hiroyuki Honda, Kensuke Sasaki, Hideomi Hamasaki, Masahiro Shijo, Sachiko Koyama, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Satoshi Suzuki, Toru Iwaki

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Abstract

We investigated the trends in dementia over the past 29 years in the town of Hisayama, Japan using 1266 autopsy specimens. The Hisayama study is a prospective cohort study of lifestyle-related diseases that was started in 1961. Clinical examination of dementia was started in 1985 with five detailed cross-sectional assessments conducted in 1985, 1992, 1998, 2005 and 2012. To examine the trends in dementia, we divided the 1266 autopsy samples into five groups according to the year of death: I (1986–1991, 257 cases), II (1992–1997, 268 cases), III (1998–2004, 318 cases), IV (2005–2011, 296 cases) and V (2012–2014, 127 cases). The prevalence of all-cause dementia significantly increased over time (28.4% in group I, 22.4% in group II, 32.1% in group III, 30.1% in group IV, 51.2% in group V; P for trend <0.001). A similar trend was observed for Alzheimer's disease (AD) (15.2%, 11.9%, 17.3%, 20.6% and 33.1%, respectively; P for trend <0.001). A significant increasing trend was observed in both men and women. A rapid increase in senile dementia of the NFT type (SD-NFT) in recent years was notable. Vascular dementia was the most common type of dementia in men prior to 2004; however, its prevalence decreased over time. Our study revealed that tauopathies, including AD and SD-NFT, significantly increased in the aged Japanese population over the course of this study. The neuritic plaque pathology of AD was associated with metabolic disorders such as insulin resistance and abnormal lipid metabolism, whereas the risk factors for tau pathology remain unclear. Although aging is considered one of the important risk factors accelerating tau pathology, there could be other risk factors associated with lifestyle diseases.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalNeuropathology
Volume36
Issue number4
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Dementia
Autopsy
Alzheimer Disease
Pathology
Life Style
Tauopathies
Vascular Dementia
Amyloid Plaques
Lipid Metabolism
Insulin Resistance
Japan
Cohort Studies
Prospective Studies
Population

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology

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Trends in autopsy-verified dementia prevalence over 29 years of the Hisayama study. / Honda, Hiroyuki; Sasaki, Kensuke; Hamasaki, Hideomi; Shijo, Masahiro; Koyama, Sachiko; Ohara, Tomoyuki; Ninomiya, Toshiharu; Kiyohara, Yutaka; Suzuki, Satoshi; Iwaki, Toru.

In: Neuropathology, Vol. 36, No. 4, 01.08.2016, p. 383-387.

Research output: Contribution to journalArticle

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abstract = "We investigated the trends in dementia over the past 29 years in the town of Hisayama, Japan using 1266 autopsy specimens. The Hisayama study is a prospective cohort study of lifestyle-related diseases that was started in 1961. Clinical examination of dementia was started in 1985 with five detailed cross-sectional assessments conducted in 1985, 1992, 1998, 2005 and 2012. To examine the trends in dementia, we divided the 1266 autopsy samples into five groups according to the year of death: I (1986–1991, 257 cases), II (1992–1997, 268 cases), III (1998–2004, 318 cases), IV (2005–2011, 296 cases) and V (2012–2014, 127 cases). The prevalence of all-cause dementia significantly increased over time (28.4{\%} in group I, 22.4{\%} in group II, 32.1{\%} in group III, 30.1{\%} in group IV, 51.2{\%} in group V; P for trend <0.001). A similar trend was observed for Alzheimer's disease (AD) (15.2{\%}, 11.9{\%}, 17.3{\%}, 20.6{\%} and 33.1{\%}, respectively; P for trend <0.001). A significant increasing trend was observed in both men and women. A rapid increase in senile dementia of the NFT type (SD-NFT) in recent years was notable. Vascular dementia was the most common type of dementia in men prior to 2004; however, its prevalence decreased over time. Our study revealed that tauopathies, including AD and SD-NFT, significantly increased in the aged Japanese population over the course of this study. The neuritic plaque pathology of AD was associated with metabolic disorders such as insulin resistance and abnormal lipid metabolism, whereas the risk factors for tau pathology remain unclear. Although aging is considered one of the important risk factors accelerating tau pathology, there could be other risk factors associated with lifestyle diseases.",
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