Trends in surgical results of hepatic resection for hepatocellular carcinoma

1,000 consecutive cases over 20 years in a single institution

Yo Ichi Yamashita, Eiji Tsuijita, kazuki takeishi, Teruyoshi Ishida, Toru Ikegami, Takuhiro Ezaki, Takashi Maeda, Tohru Utsunomiya, Naofumi Nagasue, Ken Shirabe, Yoshihiko Maehara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

BACKGROUND: Surgical results have been reported to be improved in hepatic resections for hepatocellular carcinoma (HCC) in recent years, but the detailed trends in surgical results for HCC in a single high-volume center are still not clear. METHODS: Surgical results in 1,000 hepatic resections for HCC performed at a single medical center from 1989 to 2011 were analyzed. Patients were divided into 3 groups: those performed in the early period (1989 to 1995, n = 181), the middle period (1996 to 2004, n = 391), and the late period (2005 to 2011, n = 428). RESULTS: Hospital mortality (3.9%, 1.0%, and.5%; P =.0027) and morbidity (45%, 24%, and 15%; P <.0001) rates were significantly decreased. The overall survival rates were significantly improved (50%, 72%, and 78% at 5 years; P =.0021), but there was no significant difference in the disease-free survival (29%, 34%, and 31% at 5 years; P =.7823). CONCLUSIONS: Surgical results of hepatic resections for HCC were significantly improved, with the mortality rate nearly reaching 0%. The 5-year survival rate after hepatic resections for HCC was also improved to 78%, but the consistently high rate of HCC recurrence after hepatic remains a problem.

Original languageEnglish
Pages (from-to)890-896
Number of pages7
JournalAmerican Journal of Surgery
Volume207
Issue number6
DOIs
Publication statusPublished - Jan 1 2014

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Hepatocellular Carcinoma
Liver
Survival Rate
Hospital Mortality
Disease-Free Survival
Morbidity
Recurrence
Mortality

All Science Journal Classification (ASJC) codes

  • Surgery

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Trends in surgical results of hepatic resection for hepatocellular carcinoma : 1,000 consecutive cases over 20 years in a single institution. / Yamashita, Yo Ichi; Tsuijita, Eiji; takeishi, kazuki; Ishida, Teruyoshi; Ikegami, Toru; Ezaki, Takuhiro; Maeda, Takashi; Utsunomiya, Tohru; Nagasue, Naofumi; Shirabe, Ken; Maehara, Yoshihiko.

In: American Journal of Surgery, Vol. 207, No. 6, 01.01.2014, p. 890-896.

Research output: Contribution to journalArticle

Yamashita, Yo Ichi ; Tsuijita, Eiji ; takeishi, kazuki ; Ishida, Teruyoshi ; Ikegami, Toru ; Ezaki, Takuhiro ; Maeda, Takashi ; Utsunomiya, Tohru ; Nagasue, Naofumi ; Shirabe, Ken ; Maehara, Yoshihiko. / Trends in surgical results of hepatic resection for hepatocellular carcinoma : 1,000 consecutive cases over 20 years in a single institution. In: American Journal of Surgery. 2014 ; Vol. 207, No. 6. pp. 890-896.
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