Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community - The Hisayama study

Seiji Gotoh, Jun Hata, Toshiharu Ninomiya, Yoichiro Hirakawa, Masaharu Nagata, Naoko Mukai, Masayo Fukuhara, Fumie Ikeda, Kentaro Shikata, Masahiro Kamouchi, Takanari Kitazono, Yutaka Kiyohara

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Abstract

Background: No previous population-based studies have examined secular trends in the incidence of intracerebral hemorrhage (ICH) by its location. Methods and Results: We established 3 cohorts consisting of residents of Hisayama, Japan, aged ≥40 years without a history of stroke or myocardial infarction in 1961 (the first cohort, n=1,618), in 1974 (the second cohort, n=2,038), and in 1988 (the third cohort, n=2,637). Each cohort was followed for 13 years. The age- and sex-adjusted incidence of ICH significantly declined from the first to the second cohort and showed no further change in the third cohort. With regard to the ICH location, the incidence of putaminal hemorrhage decreased steadily, mainly in subjects aged 60-69 years, whereas the incidence of thalamic hemorrhage increased, especially in those aged ≥70 years. Both hypertension and alcohol intake were strong risk factors for ICH in the first cohort, but their influence declined with time. Blood pressure levels in hypertensive subjects decreased significantly, and the proportion of current drinkers decreased slightly over the study period. Conclusions: Our findings suggest that the ICH incidence steeply declined from the 1960 s to the 1970 s in Japan as a result of the reduced influence of hypertension and alcohol intake, but that this decline has leveled off since then, probably because of the increased incidence of thalamic hemorrhage in the elderly in recent years.

Original languageEnglish
Pages (from-to)403-409
Number of pages7
JournalCirculation Journal
Volume78
Issue number2
DOIs
Publication statusPublished - Jan 30 2014

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Cerebral Hemorrhage
Incidence
Japan
Putaminal Hemorrhage
Alcohols
Hemorrhage
Hypertension
Stroke
Myocardial Infarction
Blood Pressure
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community - The Hisayama study. / Gotoh, Seiji; Hata, Jun; Ninomiya, Toshiharu; Hirakawa, Yoichiro; Nagata, Masaharu; Mukai, Naoko; Fukuhara, Masayo; Ikeda, Fumie; Shikata, Kentaro; Kamouchi, Masahiro; Kitazono, Takanari; Kiyohara, Yutaka.

In: Circulation Journal, Vol. 78, No. 2, 30.01.2014, p. 403-409.

Research output: Contribution to journalArticle

Gotoh, Seiji ; Hata, Jun ; Ninomiya, Toshiharu ; Hirakawa, Yoichiro ; Nagata, Masaharu ; Mukai, Naoko ; Fukuhara, Masayo ; Ikeda, Fumie ; Shikata, Kentaro ; Kamouchi, Masahiro ; Kitazono, Takanari ; Kiyohara, Yutaka. / Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community - The Hisayama study. In: Circulation Journal. 2014 ; Vol. 78, No. 2. pp. 403-409.
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