Trichloromethyl ketones as synthetically versatile donors: Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines

Hiroyuki Morimoto, Sean H. Wiedemann, Akitake Yamaguchi, Shinji Harada, Zhihua Chen, Shigeki Matsunaga, Masakatsu Shibasaki

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Chemical transformers! Catalytic nucleophilic activation of trichloromethyl ketones allows applications in intermolecular carbon-carbon bond-forming reactions. Mannich adducts such as azetidines can be obtained from the primary products in high yield and syn selectivity. PG = protecting group. (Chemical Equation Presented)

Original languageEnglish
Pages (from-to)3146-3150
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number19
DOIs
Publication statusPublished - May 5 2006
Externally publishedYes

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Azetidines
Ketones
Carbon
Chemical activation

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Trichloromethyl ketones as synthetically versatile donors : Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines. / Morimoto, Hiroyuki; Wiedemann, Sean H.; Yamaguchi, Akitake; Harada, Shinji; Chen, Zhihua; Matsunaga, Shigeki; Shibasaki, Masakatsu.

In: Angewandte Chemie - International Edition, Vol. 45, No. 19, 05.05.2006, p. 3146-3150.

Research output: Contribution to journalArticle

Morimoto, Hiroyuki ; Wiedemann, Sean H. ; Yamaguchi, Akitake ; Harada, Shinji ; Chen, Zhihua ; Matsunaga, Shigeki ; Shibasaki, Masakatsu. / Trichloromethyl ketones as synthetically versatile donors : Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines. In: Angewandte Chemie - International Edition. 2006 ; Vol. 45, No. 19. pp. 3146-3150.
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