Trichloromethyl ketones as synthetically versatile donors: Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines

Hiroyuki Morimoto, Sean H. Wiedemann, Akitake Yamaguchi, Shinji Harada, Zhihua Chen, Shigeki Matsunaga, Masakatsu Shibasaki

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Chemical transformers! Catalytic nucleophilic activation of trichloromethyl ketones allows applications in intermolecular carbon-carbon bond-forming reactions. Mannich adducts such as azetidines can be obtained from the primary products in high yield and syn selectivity. PG = protecting group. (Chemical Equation Presented)

Original languageEnglish
Pages (from-to)3146-3150
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number19
DOIs
Publication statusPublished - May 5 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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