Trichloromethyl ketones as synthetically versatile donors: Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines

Hiroyuki Morimoto; Sean H. Wiedemann; Akitake Yamaguchi; Shinji Harada; Zhihua Chen; Shigeki Matsunaga; Masakatsu Shibasaki

doi:10.1002/anie.200600227

Trichloromethyl ketones as synthetically versatile donors: Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines

Hiroyuki Morimoto, Sean H. Wiedemann, Akitake Yamaguchi, Shinji Harada, Zhihua Chen, Shigeki Matsunaga, Masakatsu Shibasaki

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Chemical transformers! Catalytic nucleophilic activation of trichloromethyl ketones allows applications in intermolecular carbon-carbon bond-forming reactions. Mannich adducts such as azetidines can be obtained from the primary products in high yield and syn selectivity. PG = protecting group. (Chemical Equation Presented)

Original language	English
Pages (from-to)	3146-3150
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	19
DOIs	https://doi.org/10.1002/anie.200600227
Publication status	Published - May 5 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.200600227

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Morimoto, H., Wiedemann, S. H., Yamaguchi, A., Harada, S., Chen, Z., Matsunaga, S., & Shibasaki, M. (2006). Trichloromethyl ketones as synthetically versatile donors: Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines. Angewandte Chemie - International Edition, 45(19), 3146-3150. https://doi.org/10.1002/anie.200600227

Trichloromethyl ketones as synthetically versatile donors : Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines. / Morimoto, Hiroyuki; Wiedemann, Sean H.; Yamaguchi, Akitake; Harada, Shinji; Chen, Zhihua; Matsunaga, Shigeki; Shibasaki, Masakatsu.

In: Angewandte Chemie - International Edition, Vol. 45, No. 19, 05.05.2006, p. 3146-3150.

Research output: Contribution to journal › Article › peer-review

Morimoto, H, Wiedemann, SH, Yamaguchi, A, Harada, S, Chen, Z, Matsunaga, S & Shibasaki, M 2006, 'Trichloromethyl ketones as synthetically versatile donors: Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines', Angewandte Chemie - International Edition, vol. 45, no. 19, pp. 3146-3150. https://doi.org/10.1002/anie.200600227

Morimoto, Hiroyuki ; Wiedemann, Sean H. ; Yamaguchi, Akitake ; Harada, Shinji ; Chen, Zhihua ; Matsunaga, Shigeki ; Shibasaki, Masakatsu. / Trichloromethyl ketones as synthetically versatile donors : Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines. In: Angewandte Chemie - International Edition. 2006 ; Vol. 45, No. 19. pp. 3146-3150.

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