Trifasciatosides A-J, steroidal saponins from Sansevieria trifasciata

Rémy Bertrand Teponno, Chiaki Tanaka, Bai Jie, Léon Azefack Tapondjou, Tomofumi Miyamoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Four previously unreported steroidal saponins, trifasciatosides A-D (1-4), three pairs of previously undescribed steroidal saponins, trifasciatosides E-J (5a, b-7a, b) including acetylated ones, together with twelve known compounds were isolated from the n-butanol soluble fraction of the methanol extract of Sansevieria trifasciata. Their structures were elucidated on the basis of detailed spectroscopic analysis, including 1H-NMR, 13C-NMR, 1H-1H correlated spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC), total correlated spectroscopy (TOCSY), nuclear Overhauser enhancement and exchange spectroscopy (NOESY), electrospray ionization-time of flight (ESI-TOF)-MS and chemical methods. Compounds 2, 4, and 7a, b exhibited moderate antiproliferative activity against HeLa cells.

Original languageEnglish
Pages (from-to)1347-1355
Number of pages9
JournalChemical and Pharmaceutical Bulletin
Volume64
Issue number9
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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