Trim33 mediates the proinflammatory function of Th17 cells

Shinya Tanaka, Yu Jiang, Gustavo J. Martinez, Kentaro Tanaka, Xiaowei Yan, Tomohiro Kurosaki, Vesa Kaartinen, Xin Hua Feng, Qiang Tian, Xiaohu Wang, Chen Dong

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Transforming growth factor–β (TGF-β) regulates reciprocal regulatory T cell (T reg) and T helper 17 (Th17) differentiation, the underlying mechanism of which is still not understood. Here, we report that tripartite motif-containing 33 (Trim33), a modulator of TGF-β signaling that associates with Smad2, regulates the proinflammatory function of Th17 cells. Trim33 deficiency in T cells ameliorated an autoimmune disease in vivo. Trim33 was required for induction in vitro of Th17, but not T reg cells. Moreover, Smad4 and Trim33 play contrasting roles in the regulation of IL-10 expression; loss of Trim33 enhanced IL-10 production. Furthermore, Trim33 was recruited to the Il17a and Il10 gene loci, dependent on Smad2, and mediated their chromatin remodeling during Th17 differentiation. Trim33 thus promotes the proinflammatory function of Th17 cells by inducing IL-17 and suppressing IL-10 expression.

Original languageEnglish
Pages (from-to)1853-1868
Number of pages16
JournalJournal of Experimental Medicine
Volume215
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Tanaka, S., Jiang, Y., Martinez, G. J., Tanaka, K., Yan, X., Kurosaki, T., Kaartinen, V., Feng, X. H., Tian, Q., Wang, X., & Dong, C. (2018). Trim33 mediates the proinflammatory function of Th17 cells. Journal of Experimental Medicine, 215(7), 1853-1868. https://doi.org/10.1084/jem.20170779