Trim36/Haprin plays a critical role in the arrangement of somites during Xenopus embryogenesis

Emi Yoshigai, Shinobu Kawamura, Satoru Kuhara, Kosuke Tashiro

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The TRIM family members contain a tripartite motif (TRIM), which includes RING, B-box, and coiled-coil domains, or collectively RBCC. They have been implicated in a variety of biological processes, such as the regulation of differentiation and development, and oncogenesis. In this study, we discovered a novel function of the TRIM family in early development. We report the expression of Trim36/Haprin during Xenopus laevis early embryogenesis and its involvement in somite formation. Temporal expression analysis indicated that Trim36/Haprin was present throughout embryogenesis. Spatial expression analysis showed that its expression was mainly confined to the nervous system and a portion of the posterior somite. Morpholino-mediated knockdown of Trim36/Haprin markedly and specifically inhibited the somite formation. We conclude that Trim36/Haprin plays an important role in the arrangement of somites during their formation.

Original languageEnglish
Pages (from-to)428-432
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume378
Issue number3
DOIs
Publication statusPublished - Jan 16 2009

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Somites
Xenopus
Embryonic Development
Biological Phenomena
Morpholinos
Spatial Analysis
Xenopus laevis
Neurology
Nervous System
Carcinogenesis
haprin

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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Trim36/Haprin plays a critical role in the arrangement of somites during Xenopus embryogenesis. / Yoshigai, Emi; Kawamura, Shinobu; Kuhara, Satoru; Tashiro, Kosuke.

In: Biochemical and Biophysical Research Communications, Vol. 378, No. 3, 16.01.2009, p. 428-432.

Research output: Contribution to journalArticle

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