Trimester-Specific Association of Maternal Exposure to Fine Particulate Matter and its Components With Birth and Placental Weight in Japan

Yuki Takeda, Takehiro Michikawa, Seiichi Morokuma, Shin Yamazaki, Kazushige Nakahara, Ayako Yoshino, Seiji Sugata, Akinori Takami, Shinji Saito, Junya Hoshi, Kiyoko Kato, Hiroshi Nitta, Yuji Nishiwaki

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: We investigated which trimester of exposure to PM2.5 and its components was associated with birth and placental weight, and the fetoplacental weight ratio. METHODS: The study included 63,990 women who delivered singleton term births within 23 Tokyo wards between 2013 and 2015. Each day, we collected fine particles on a filter, and analyzed their chemical constituents, including carbons and ions. Trimester-specific exposure to each pollutant was estimated based on the average daily concentrations. RESULTS: Over the third trimester, sulfate exposure tended to be inversely associated with birth weight, and decreased placental weight (difference for highest vs lowest quintile groups = -6.7 g, 95% confidence interval = -12.5 to -0.9). For fetoplacental weight ratio, there was no relationship. CONCLUSIONS: Sulfate exposure over the third trimester may reduce birth weight, particularly placental weight.

Original languageEnglish
Pages (from-to)771-778
Number of pages8
JournalJournal of Occupational and Environmental Medicine
Volume63
Issue number9
DOIs
Publication statusPublished - Sep 1 2021

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

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