TY - JOUR
T1 - Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer
AU - Kosaka, Yoshimasa
AU - Inoue, Hiroshi
AU - Ohmachi, Takahiro
AU - Yokoe, Takeshi
AU - Matsumoto, Toshifumi
AU - Mimori, Koshi
AU - Tanaka, Fumiaki
AU - Watanabe, Masahiko
AU - Mori, Masaki
N1 - Funding Information:
Supported in part by CREST, Japan Science and Technology Agency (JST); Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research (grants 17109013, 17591411, 17591413, 18390367, 18590333, 18659384, and 18790964); and Ministry of Education, Culture, Sports, Science and Technology (MEXT) Grant-in-Aid for Scientific Research on Priority Areas (grant 18015039), third term. We thank T. Shimooka, K. Ogata, M. Oda, N. Kasagi, and Y. Nakagawa for technical assistance.
PY - 2007/9
Y1 - 2007/9
N2 - Background: Tripartite motif-containing 29 (TRIM29) belongs to the TRIM protein family, which has unique structural characteristics, including multiple zinc finger motifs and a leucine zipper motif. TRIM29, also known as ataxia telangiectasia group D complementing gene, possesses radiosensitivity suppressor functions. Although TRIM29 has been reported to be underexpressed in prostate and breast cancer, its expression in gastrointestinal cancer has not been studied. Methods: By use of real-time reverse transcriptase-polymerase chain reaction, we analyzed TRIM29 mRNA expression status with respect to various clinicopathological parameters in 124 patients with gastric cancer. An immunohistochemical study was also conducted. Results: The expression of TRIM29 was far higher in gastric cancer tumor tissue. Increased TRIM29 mRNA expression was markedly associated with such parameters as histological grade, large tumor size, extent of tumor invasion, and lymph node metastasis. In the TRIM29 high-expression group, it was an independent predictor for lymph node metastasis. Furthermore, patients with high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression. Conclusions: TRIM29 expression may serve as a good marker of lymph node metastasis in gastric cancer.
AB - Background: Tripartite motif-containing 29 (TRIM29) belongs to the TRIM protein family, which has unique structural characteristics, including multiple zinc finger motifs and a leucine zipper motif. TRIM29, also known as ataxia telangiectasia group D complementing gene, possesses radiosensitivity suppressor functions. Although TRIM29 has been reported to be underexpressed in prostate and breast cancer, its expression in gastrointestinal cancer has not been studied. Methods: By use of real-time reverse transcriptase-polymerase chain reaction, we analyzed TRIM29 mRNA expression status with respect to various clinicopathological parameters in 124 patients with gastric cancer. An immunohistochemical study was also conducted. Results: The expression of TRIM29 was far higher in gastric cancer tumor tissue. Increased TRIM29 mRNA expression was markedly associated with such parameters as histological grade, large tumor size, extent of tumor invasion, and lymph node metastasis. In the TRIM29 high-expression group, it was an independent predictor for lymph node metastasis. Furthermore, patients with high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression. Conclusions: TRIM29 expression may serve as a good marker of lymph node metastasis in gastric cancer.
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U2 - 10.1245/s10434-007-9461-1
DO - 10.1245/s10434-007-9461-1
M3 - Article
C2 - 17597343
AN - SCOPUS:34548573537
SN - 1068-9265
VL - 14
SP - 2543
EP - 2549
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 9
ER -
