Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer

Yoshimasa Kosaka, Hiroshi Inoue, Takahiro Ohmachi, Takeshi Yokoe, Toshifumi Matsumoto, Koshi Mimori, Fumiaki Tanaka, Masahiko Watanabe, Masaki Mori

Research output: Contribution to journalArticle

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Abstract

Background: Tripartite motif-containing 29 (TRIM29) belongs to the TRIM protein family, which has unique structural characteristics, including multiple zinc finger motifs and a leucine zipper motif. TRIM29, also known as ataxia telangiectasia group D complementing gene, possesses radiosensitivity suppressor functions. Although TRIM29 has been reported to be underexpressed in prostate and breast cancer, its expression in gastrointestinal cancer has not been studied. Methods: By use of real-time reverse transcriptase-polymerase chain reaction, we analyzed TRIM29 mRNA expression status with respect to various clinicopathological parameters in 124 patients with gastric cancer. An immunohistochemical study was also conducted. Results: The expression of TRIM29 was far higher in gastric cancer tumor tissue. Increased TRIM29 mRNA expression was markedly associated with such parameters as histological grade, large tumor size, extent of tumor invasion, and lymph node metastasis. In the TRIM29 high-expression group, it was an independent predictor for lymph node metastasis. Furthermore, patients with high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression. Conclusions: TRIM29 expression may serve as a good marker of lymph node metastasis in gastric cancer.

Original languageEnglish
Pages (from-to)2543-2549
Number of pages7
JournalAnnals of Surgical Oncology
Volume14
Issue number9
DOIs
Publication statusPublished - Sep 1 2007

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Stomach Neoplasms
Lymph Nodes
Neoplasm Metastasis
Messenger RNA
Leucine Zippers
Ataxia Telangiectasia
Neoplasms
Gastrointestinal Neoplasms
Radiation Tolerance
Zinc Fingers
Reverse Transcriptase Polymerase Chain Reaction
Real-Time Polymerase Chain Reaction
Prostatic Neoplasms
Survival Rate
Breast Neoplasms
Genes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. / Kosaka, Yoshimasa; Inoue, Hiroshi; Ohmachi, Takahiro; Yokoe, Takeshi; Matsumoto, Toshifumi; Mimori, Koshi; Tanaka, Fumiaki; Watanabe, Masahiko; Mori, Masaki.

In: Annals of Surgical Oncology, Vol. 14, No. 9, 01.09.2007, p. 2543-2549.

Research output: Contribution to journalArticle

Kosaka, Yoshimasa ; Inoue, Hiroshi ; Ohmachi, Takahiro ; Yokoe, Takeshi ; Matsumoto, Toshifumi ; Mimori, Koshi ; Tanaka, Fumiaki ; Watanabe, Masahiko ; Mori, Masaki. / Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. In: Annals of Surgical Oncology. 2007 ; Vol. 14, No. 9. pp. 2543-2549.
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abstract = "Background: Tripartite motif-containing 29 (TRIM29) belongs to the TRIM protein family, which has unique structural characteristics, including multiple zinc finger motifs and a leucine zipper motif. TRIM29, also known as ataxia telangiectasia group D complementing gene, possesses radiosensitivity suppressor functions. Although TRIM29 has been reported to be underexpressed in prostate and breast cancer, its expression in gastrointestinal cancer has not been studied. Methods: By use of real-time reverse transcriptase-polymerase chain reaction, we analyzed TRIM29 mRNA expression status with respect to various clinicopathological parameters in 124 patients with gastric cancer. An immunohistochemical study was also conducted. Results: The expression of TRIM29 was far higher in gastric cancer tumor tissue. Increased TRIM29 mRNA expression was markedly associated with such parameters as histological grade, large tumor size, extent of tumor invasion, and lymph node metastasis. In the TRIM29 high-expression group, it was an independent predictor for lymph node metastasis. Furthermore, patients with high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression. Conclusions: TRIM29 expression may serve as a good marker of lymph node metastasis in gastric cancer.",
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AU - Matsumoto, Toshifumi

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