Triterpene saponins from cyclamen trocopteranthum

Ghezala Mihci-Gaidi, Suheyla Ozbey, Ilkay Orhan, Bilge Sener, Tomofumi Miyamoto, Jean François Mirjolet, Olivier Duchamp, Anne Claire Mitaine-Offer, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Two new triterpene saponins (12) together with three known saponins, deglucocyclamin I (3), cyclamin (4), and mirabilin (5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3-O-{4-O-[3- hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12) - D-glucopyranosyl-(14)-[-D- glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-13,28-epoxy-oleanan-30-al (1) and 3-O-{4-O-[3-hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12)-[-D- glucopyranosyl-(16)] - D-glucopyranosyl-(14)-[-D-glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-20,30-lactone-olean-12-ene (2). Their structures were characterized mainly by a combination of 1D- and 2DNMR techniques ( 1H-1H COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectroscopy. Saponins 1, 3, and 4 showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells.

Original languageEnglish
Pages (from-to)818-821
Number of pages4
JournalPlanta medica
Volume76
Issue number8
DOIs
Publication statusPublished - Jun 4 2010

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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