TY - JOUR
T1 - Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)
AU - Awang, Khalijah
AU - Loong, Xe Min
AU - Leong, Kok Hoong
AU - Supratman, Unang
AU - Litaudon, Marc
AU - Mukhtar, Mat Ropi
AU - Mohamad, Khalit
N1 - Funding Information:
This work was supported by grant from the Institute of Research Management and Monitoring (IPPP) ( PS344/2009C ), Fundamental Research Grant Scheme (FRGS) ( FP006/2011A ) and Research University Grant ( RP001/2012A ). We thank D. M. Nor (University of Malaya) for the collection of plant material and Mr. Teo Leong Eng for the botanical identification. This work was carried out within the framework of an official agreement between the University of Malaya (Malaysia) and CNRS (France).
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/12
Y1 - 2012/12
N2 - A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM).
AB - A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM).
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U2 - 10.1016/j.fitote.2012.10.004
DO - 10.1016/j.fitote.2012.10.004
M3 - Article
C2 - 23098876
AN - SCOPUS:84870826315
SN - 0367-326X
VL - 83
SP - 1391
EP - 1395
JO - Fitoterapia
JF - Fitoterapia
IS - 8
ER -
