Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)

Khalijah Awang, Xe Min Loong, Kok Hoong Leong, Unang Supratman, Marc Litaudon, Mat Ropi Mukhtar, Khalit Mohamad

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM).

Original languageEnglish
Pages (from-to)1391-1395
Number of pages5
JournalFitoterapia
Volume83
Issue number8
DOIs
Publication statusPublished - Dec 1 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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    Awang, K., Loong, X. M., Leong, K. H., Supratman, U., Litaudon, M., Mukhtar, M. R., & Mohamad, K. (2012). Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae). Fitoterapia, 83(8), 1391-1395. https://doi.org/10.1016/j.fitote.2012.10.004