Triterpenoid saponins from Polycarpaea corymbosa Lamk. var. eriantha Hochst

Mahenina Jaovita Manase, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Stéphanie Delemasure, Patrick Dutartre, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Four triterpenoid saponins (1-4) were isolated from Polycarpaea corymbosa Lamk. var. eriantha Hochst along with the known apoanagallosaponin IV (5). Their structures were elucidated by spectroscopic data analysis. Among the compounds 1, 3-5 which were evaluated for their cytotoxicity against three tumor cell lines (SW480, DU145 and EMT6), compound 1 exhibited cytotoxicity with IC 50 values ranging from 4.61 to 22.61 μM, which was greater than that of etoposide. Compound 2 was tested only against SW480 and a cardiomyoblast cell line (H9c2), and was inactive.

Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalPhytochemistry
Volume100
DOIs
Publication statusPublished - Apr 1 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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