Triterpenoid saponins from Polycarpaea corymbosa Lamk. var. eriantha Hochst

Mahenina Jaovita Manase, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Stéphanie Delemasure, Patrick Dutartre, Marie Aleth Lacaille-Dubois

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Abstract

Four triterpenoid saponins (1-4) were isolated from Polycarpaea corymbosa Lamk. var. eriantha Hochst along with the known apoanagallosaponin IV (5). Their structures were elucidated by spectroscopic data analysis. Among the compounds 1, 3-5 which were evaluated for their cytotoxicity against three tumor cell lines (SW480, DU145 and EMT6), compound 1 exhibited cytotoxicity with IC 50 values ranging from 4.61 to 22.61 μM, which was greater than that of etoposide. Compound 2 was tested only against SW480 and a cardiomyoblast cell line (H9c2), and was inactive.

Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalPhytochemistry
Volume100
DOIs
Publication statusPublished - Apr 1 2014

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

Cite this

Manase, M. J., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Delemasure, S., Dutartre, P., & Lacaille-Dubois, M. A. (2014). Triterpenoid saponins from Polycarpaea corymbosa Lamk. var. eriantha Hochst. Phytochemistry, 100, 150-155. https://doi.org/10.1016/j.phytochem.2013.12.005