Triterpenoid saponins from the roots of two Gypsophila species

David Pertuit, Sibel Avunduk, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Thomas Paululat, Stéphanie Delemasure, Patrick Dutartre, Marie Aleth Lacaille-Dubois

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15 Citations (Scopus)

Abstract

Two triterpenoid saponins with two known ones have been isolated from the roots of Gypsophila arrostii var. nebulosa, and two new ones from the roots of Gypsophila bicolor. Their structures were established by extensive NMR and mass spectroscopic techniques as 3-O-β-d-galactopyranosyl-(1→2)-[β-d- xylopyranosyl-(1→3)]-β-d-glucuronopyranosylquillaic acid 28-O-β-d-xylopyranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)] -α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)] -β-d-fucopyranosyl ester (1), 3-O-β-d-galactopyranosyl-(1→2)- [β-d-xylopyranosyl-(1→3)]-β-d-glucuronopyranosylgypsogenin 28-O-β-d-xylopyranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)] -α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)] -β-d-fucopyranosyl ester (2), 3-O-β-d-galactopyranosyl-(1→2)- [β-d-xylopyranosyl-(1→3)]-β-d-glucuronopyranosylgypsogenin 28-O-β-d-xylopyranosyl-(1→3)-β-d-xylopyranosyl-(1→4) -α-l-rhamnopyranosyl-(1→2)-[(4-O-acetyl)-β-d-quinovopyranosyl- (1→4)]-β-d-fucopyranosyl ester (3), gypsogenic acid 28-O-β-d-glucopyranosyl-(1→3)-{6-O-[3-hydroxy-3-methylglutaryl] -β-d-glucopyranosyl-(1→6)}-β-d-galactopyranosyl ester (4). Three compounds were evaluated against one human colon cancer cell line SW480 and one rat cardiomyoblast cell line H9c2.

Original languageEnglish
Pages (from-to)182-188
Number of pages7
JournalPhytochemistry
Volume102
DOIs
Publication statusPublished - Jun 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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    Pertuit, D., Avunduk, S., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Paululat, T., Delemasure, S., Dutartre, P., & Lacaille-Dubois, M. A. (2014). Triterpenoid saponins from the roots of two Gypsophila species. Phytochemistry, 102, 182-188. https://doi.org/10.1016/j.phytochem.2014.02.018