Troponin isoform dependent pH dependence of the Ca2+-activated myofibrillar atpase activity of avian slow and fast skeletal muscles

Akira Kawashima, Sachio Morimoto, Akito Suzuki, Fumie Shiraishi, Iwao Ohtsuki

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The effects of acidic pH were examined on the Ca2+-sensitive ATPase activity of chicken fast and slow skeletal muscle myofibrils. In both types of myofibrils the Ca2+-sensitivity declined on decreasing pH from 7.4 to 6.2, but the slow skeletal muscle myofibrils were found to exhibit a Ca2+-sensitive ATPase activity which was more resistant to acidic pH compared to the fast skeletal muscle myofibrils. The results obtained by using a novel method for replacing whole troponin complex in myofibrils provide the first evidence that troponin is responsible for this higher resistibility of slow skeletal muscle myofibrils to acidosis.

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - Jan 1 1995

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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