T mapping improvement using stretched-type adiabatic locking pulses for assessment of human liver function at 3 T

Tomoyuki Okuaki, Yukihisa Takayama, Akihiro Nishie, Tetsuo Ogino, Makoto Obara, Hiroshi Honda, Tosiaki Miyati, Marc Van Cauteren

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Abstract

Purpose The purpose of this study is to investigate the performance of stretched-type adiabatic spin lock pulses for homogeneous spin locking with a flexible spin lock time (TSL) setting. Methods T values were obtained from 61 patients and five normal volunteers who were categorized using the Child–Pugh classification and scanned using each spin lock pulse type. The pulses used were the block and two kinds of hyperbolic secant (HS); HS8_10, and HS8_5. Visual scoring was categorized using a four point scale (1:Severe, 2:Moderate, 3:Mild and 4:None) to evaluate the homogeneity of the T map and the source images obtained by each spin lock pulse. Mean T values among the patient groups with different Child–Pugh classification were compared. Results The visual assessment scores were 1.98 ± 1.05 for block pulse locking, 3.87 ± 0.39 for HS8_10 pulse locking, and 3.83 ± 0.45 for HS8_5 pulse locking, respectively. The scores between block pulse and HS8_10 were significantly different (p < 0.001), as were those between block pulse and HS8_5 (p < 0.001). The median T values of normal liver function, Child–Pugh A, and Child–Pugh B or C were 37.00 ms, 40.77 ms, and 42.20 ms for block pulse, 46.75 ms, 50.78 ms, and 55.60 ms for HS8_10, and 48.80 ms, 55.42 ms, and 57.80 ms for HS8_5, respectively. Conclusion The spin locking sequence using stretched-type adiabatic pulses provides homogeneous liver T maps with reduced artifact and is necessary for a robust evaluation of liver function using T.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalMagnetic Resonance Imaging
Volume40
DOIs
Publication statusPublished - Jul 1 2017

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Liver
Artifacts
Healthy Volunteers
Reference Values

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

T mapping improvement using stretched-type adiabatic locking pulses for assessment of human liver function at 3 T. / Okuaki, Tomoyuki; Takayama, Yukihisa; Nishie, Akihiro; Ogino, Tetsuo; Obara, Makoto; Honda, Hiroshi; Miyati, Tosiaki; Van Cauteren, Marc.

In: Magnetic Resonance Imaging, Vol. 40, 01.07.2017, p. 17-23.

Research output: Contribution to journalArticle

Okuaki, Tomoyuki ; Takayama, Yukihisa ; Nishie, Akihiro ; Ogino, Tetsuo ; Obara, Makoto ; Honda, Hiroshi ; Miyati, Tosiaki ; Van Cauteren, Marc. / T mapping improvement using stretched-type adiabatic locking pulses for assessment of human liver function at 3 T. In: Magnetic Resonance Imaging. 2017 ; Vol. 40. pp. 17-23.
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title = "T1ρ mapping improvement using stretched-type adiabatic locking pulses for assessment of human liver function at 3 T",
abstract = "Purpose The purpose of this study is to investigate the performance of stretched-type adiabatic spin lock pulses for homogeneous spin locking with a flexible spin lock time (TSL) setting. Methods T1ρ values were obtained from 61 patients and five normal volunteers who were categorized using the Child–Pugh classification and scanned using each spin lock pulse type. The pulses used were the block and two kinds of hyperbolic secant (HS); HS8_10, and HS8_5. Visual scoring was categorized using a four point scale (1:Severe, 2:Moderate, 3:Mild and 4:None) to evaluate the homogeneity of the T1ρ map and the source images obtained by each spin lock pulse. Mean T1ρ values among the patient groups with different Child–Pugh classification were compared. Results The visual assessment scores were 1.98 ± 1.05 for block pulse locking, 3.87 ± 0.39 for HS8_10 pulse locking, and 3.83 ± 0.45 for HS8_5 pulse locking, respectively. The scores between block pulse and HS8_10 were significantly different (p < 0.001), as were those between block pulse and HS8_5 (p < 0.001). The median T1ρ values of normal liver function, Child–Pugh A, and Child–Pugh B or C were 37.00 ms, 40.77 ms, and 42.20 ms for block pulse, 46.75 ms, 50.78 ms, and 55.60 ms for HS8_10, and 48.80 ms, 55.42 ms, and 57.80 ms for HS8_5, respectively. Conclusion The spin locking sequence using stretched-type adiabatic pulses provides homogeneous liver T1ρ maps with reduced artifact and is necessary for a robust evaluation of liver function using T1ρ.",
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AU - Okuaki, Tomoyuki

AU - Takayama, Yukihisa

AU - Nishie, Akihiro

AU - Ogino, Tetsuo

AU - Obara, Makoto

AU - Honda, Hiroshi

AU - Miyati, Tosiaki

AU - Van Cauteren, Marc

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N2 - Purpose The purpose of this study is to investigate the performance of stretched-type adiabatic spin lock pulses for homogeneous spin locking with a flexible spin lock time (TSL) setting. Methods T1ρ values were obtained from 61 patients and five normal volunteers who were categorized using the Child–Pugh classification and scanned using each spin lock pulse type. The pulses used were the block and two kinds of hyperbolic secant (HS); HS8_10, and HS8_5. Visual scoring was categorized using a four point scale (1:Severe, 2:Moderate, 3:Mild and 4:None) to evaluate the homogeneity of the T1ρ map and the source images obtained by each spin lock pulse. Mean T1ρ values among the patient groups with different Child–Pugh classification were compared. Results The visual assessment scores were 1.98 ± 1.05 for block pulse locking, 3.87 ± 0.39 for HS8_10 pulse locking, and 3.83 ± 0.45 for HS8_5 pulse locking, respectively. The scores between block pulse and HS8_10 were significantly different (p < 0.001), as were those between block pulse and HS8_5 (p < 0.001). The median T1ρ values of normal liver function, Child–Pugh A, and Child–Pugh B or C were 37.00 ms, 40.77 ms, and 42.20 ms for block pulse, 46.75 ms, 50.78 ms, and 55.60 ms for HS8_10, and 48.80 ms, 55.42 ms, and 57.80 ms for HS8_5, respectively. Conclusion The spin locking sequence using stretched-type adiabatic pulses provides homogeneous liver T1ρ maps with reduced artifact and is necessary for a robust evaluation of liver function using T1ρ.

AB - Purpose The purpose of this study is to investigate the performance of stretched-type adiabatic spin lock pulses for homogeneous spin locking with a flexible spin lock time (TSL) setting. Methods T1ρ values were obtained from 61 patients and five normal volunteers who were categorized using the Child–Pugh classification and scanned using each spin lock pulse type. The pulses used were the block and two kinds of hyperbolic secant (HS); HS8_10, and HS8_5. Visual scoring was categorized using a four point scale (1:Severe, 2:Moderate, 3:Mild and 4:None) to evaluate the homogeneity of the T1ρ map and the source images obtained by each spin lock pulse. Mean T1ρ values among the patient groups with different Child–Pugh classification were compared. Results The visual assessment scores were 1.98 ± 1.05 for block pulse locking, 3.87 ± 0.39 for HS8_10 pulse locking, and 3.83 ± 0.45 for HS8_5 pulse locking, respectively. The scores between block pulse and HS8_10 were significantly different (p < 0.001), as were those between block pulse and HS8_5 (p < 0.001). The median T1ρ values of normal liver function, Child–Pugh A, and Child–Pugh B or C were 37.00 ms, 40.77 ms, and 42.20 ms for block pulse, 46.75 ms, 50.78 ms, and 55.60 ms for HS8_10, and 48.80 ms, 55.42 ms, and 57.80 ms for HS8_5, respectively. Conclusion The spin locking sequence using stretched-type adiabatic pulses provides homogeneous liver T1ρ maps with reduced artifact and is necessary for a robust evaluation of liver function using T1ρ.

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