T1ρ Relaxation of the liver: A potential biomarker of liver function

Yukihisa Takayama, Akihiro Nishie, Yoshiki Asayama, Yasuhiro Ushijima, Daisuke Okamoto, Nobuhiro Fujita, Koichiro Morita, Ken Shirabe, Kazuhiro Kotoh, Yuichiro Kubo, Tomoyuki Okuaki, Hiroshi Honda

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Abstract

Purpose To investigate the diagnostic potential of T1ρ relaxation for assessing liver function, liver fibrosis, or liver necroinflammation in patients with chronic liver disease (CLD). Materials and Methods We obtained T1ρ maps of the liver for 53 patients with or without CLD. We measured the T1ρ values of the liver and correlated them with the results of laboratory tests and histological examinations. Pearson's correlation coefficients (r) were calculated between the T1ρ values and blood serum parameters including the retention rates at 15 minutes after an injection of indocyanine green (ICG-R15). Spearman's rank correlation coefficients were calculated between the T1ρ values and the scores of liver fibrosis or liver necroinflammation. Results The T1ρ values showed significant positive correlations with the serum levels of total bilirubin (r=0.31, P<0.05), direct bilirubin (r=0.32, P<0.05), and ICG-R15 (r=0.46, P<0.05), and significant negative correlations with the serum levels of albumin (r=-0.33, P<0.05) and γ-glutamyl transpeptidase (r=-0.28, P<0.05). However, there were no significant correlations between the T1ρ value and the scores of liver fibrosis (P=0.95) or liver necroinflammation (P=0.86). Conclusion T1ρ relaxation has potential as a biomarker of liver function in patients with CLD. However, it may not be suitable to estimate liver fibrosis or liver necroinflammation.

Original languageEnglish
Pages (from-to)188-195
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume42
Issue number1
DOIs
Publication statusPublished - Jul 1 2015

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Biomarkers
Liver
Liver Cirrhosis
Liver Diseases
Chronic Disease
Bilirubin
Indocyanine Green
gamma-Glutamyltransferase
Nonparametric Statistics
Serum
Serum Albumin
Injections

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

T1ρ Relaxation of the liver : A potential biomarker of liver function. / Takayama, Yukihisa; Nishie, Akihiro; Asayama, Yoshiki; Ushijima, Yasuhiro; Okamoto, Daisuke; Fujita, Nobuhiro; Morita, Koichiro; Shirabe, Ken; Kotoh, Kazuhiro; Kubo, Yuichiro; Okuaki, Tomoyuki; Honda, Hiroshi.

In: Journal of Magnetic Resonance Imaging, Vol. 42, No. 1, 01.07.2015, p. 188-195.

Research output: Contribution to journalArticle

Takayama, Yukihisa ; Nishie, Akihiro ; Asayama, Yoshiki ; Ushijima, Yasuhiro ; Okamoto, Daisuke ; Fujita, Nobuhiro ; Morita, Koichiro ; Shirabe, Ken ; Kotoh, Kazuhiro ; Kubo, Yuichiro ; Okuaki, Tomoyuki ; Honda, Hiroshi. / T1ρ Relaxation of the liver : A potential biomarker of liver function. In: Journal of Magnetic Resonance Imaging. 2015 ; Vol. 42, No. 1. pp. 188-195.
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T2 - A potential biomarker of liver function

AU - Takayama, Yukihisa

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AU - Asayama, Yoshiki

AU - Ushijima, Yasuhiro

AU - Okamoto, Daisuke

AU - Fujita, Nobuhiro

AU - Morita, Koichiro

AU - Shirabe, Ken

AU - Kotoh, Kazuhiro

AU - Kubo, Yuichiro

AU - Okuaki, Tomoyuki

AU - Honda, Hiroshi

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Purpose To investigate the diagnostic potential of T1ρ relaxation for assessing liver function, liver fibrosis, or liver necroinflammation in patients with chronic liver disease (CLD). Materials and Methods We obtained T1ρ maps of the liver for 53 patients with or without CLD. We measured the T1ρ values of the liver and correlated them with the results of laboratory tests and histological examinations. Pearson's correlation coefficients (r) were calculated between the T1ρ values and blood serum parameters including the retention rates at 15 minutes after an injection of indocyanine green (ICG-R15). Spearman's rank correlation coefficients were calculated between the T1ρ values and the scores of liver fibrosis or liver necroinflammation. Results The T1ρ values showed significant positive correlations with the serum levels of total bilirubin (r=0.31, P<0.05), direct bilirubin (r=0.32, P<0.05), and ICG-R15 (r=0.46, P<0.05), and significant negative correlations with the serum levels of albumin (r=-0.33, P<0.05) and γ-glutamyl transpeptidase (r=-0.28, P<0.05). However, there were no significant correlations between the T1ρ value and the scores of liver fibrosis (P=0.95) or liver necroinflammation (P=0.86). Conclusion T1ρ relaxation has potential as a biomarker of liver function in patients with CLD. However, it may not be suitable to estimate liver fibrosis or liver necroinflammation.

AB - Purpose To investigate the diagnostic potential of T1ρ relaxation for assessing liver function, liver fibrosis, or liver necroinflammation in patients with chronic liver disease (CLD). Materials and Methods We obtained T1ρ maps of the liver for 53 patients with or without CLD. We measured the T1ρ values of the liver and correlated them with the results of laboratory tests and histological examinations. Pearson's correlation coefficients (r) were calculated between the T1ρ values and blood serum parameters including the retention rates at 15 minutes after an injection of indocyanine green (ICG-R15). Spearman's rank correlation coefficients were calculated between the T1ρ values and the scores of liver fibrosis or liver necroinflammation. Results The T1ρ values showed significant positive correlations with the serum levels of total bilirubin (r=0.31, P<0.05), direct bilirubin (r=0.32, P<0.05), and ICG-R15 (r=0.46, P<0.05), and significant negative correlations with the serum levels of albumin (r=-0.33, P<0.05) and γ-glutamyl transpeptidase (r=-0.28, P<0.05). However, there were no significant correlations between the T1ρ value and the scores of liver fibrosis (P=0.95) or liver necroinflammation (P=0.86). Conclusion T1ρ relaxation has potential as a biomarker of liver function in patients with CLD. However, it may not be suitable to estimate liver fibrosis or liver necroinflammation.

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