Tsukushi is required for anterior commissure formation in mouse brain

Ayako Ito, Yohei Shinmyo, Takaya Abe, Naoko Oshima, Hideaki Tanaka, Kunimasa Ohta

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The anterior commissure (AC) is one of the important commissure projections in the brain that conveys information from one side of the nervous system to the other. During development, the axons from the anterior AC (aAC) and the posterior AC (pAC) course in the same dorsoventral plane and converge into a common fascicle for midline crossing. Previously, we reported that Tsukushi (TSK), a member of the secreted small leucine rich repeat proteoglycan family, functions as a key coordinator of multiple pathways outside of cells through the regulation of an extracellular signaling network. Here, we show evidence that TSK is critical for the formation of the AC. In mice lacking TSK, the aAC and the pAC axons fail to cross the midline, leading to an almost total absence of the AC in adult mice. DiI labeling indicated that the aAC axons grew out from the anterior olfactory nucleus and migrated along normal pathways but never crossed the midline. Therefore, we have uncovered a crucial role for TSK for AC formation in the mouse brain.

Original languageEnglish
Pages (from-to)813-818
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume402
Issue number4
DOIs
Publication statusPublished - Nov 26 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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