T-786 → C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis

Masafumi Nakayama, Hirofumi Yasue, Michihiro Yoshimura, Yukio Shimasaki, Hisao Ogawa, Kiyotaka Kugiyama, Yuji Mizuno, Eisaku Harada, Shota Nakamura, Teruhiko Ito, Yoshihiko Saito, Yoshihiro Miyamoto, Yoshihiro Ogawa, Kazuwa Nakao

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Recently, we discovered a T-786 → C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene that is associated with coronary spasm. The precise mechanism(s) of myocardial infarction (MI), especially without coronary organic stenosis, has not been elucidated, but it seems possible that coronary spasm plays a key role in the mechanism. In this study, we examined the frequency with which the T-786 → C mutation occurred in 359 patients with MI who were compared with 195 controls. In the MI group, the frequency of C/C, C/T, and T/T genotypes was 1%, 22%, and 77%, respectively. In the control group, the frequency of C/C, C/T, and T/T genotypes were 0%, 8%, and 92%, respectively. The frequency of the C allele was significantly higher in the MI group than in the control group (p < 0.001). In the MI group, 30 of 359 patients (8%) with MI had no stenosed vessels angiographically, 158 (44%) had 1 stenosed vessel, 80 (22%) had 2 stenosed vessels, and 91 (25%) exhibited 3 stenosed vessels. Total and low- density lipoprotein cholesterol levels and the incidence of diabetes mellitus increased as the number of stenosed vessels increased (p < 0.01, respectively). The frequency of the T-786 → C mutation was significantly higher in MI patients with no stenosed vessels (50%) than in those with stenosed vessels (p < 0.003). In conclusion, the T-786 → C mutation was strongly associated with MI, especially without coronary arterial stenosis, in Japanese patients. The association may be due to the impaired effects of nitric oxide in the cardiovascular system. (C) 2000 by Excerpta Medica, Inc.

Original languageEnglish
Pages (from-to)628-634
Number of pages7
JournalAmerican Journal of Cardiology
Volume86
Issue number6
DOIs
Publication statusPublished - Sep 15 2000

Fingerprint

Nitric Oxide Synthase Type III
5' Flanking Region
Coronary Stenosis
Myocardial Infarction
Mutation
Genes
Spasm
Genotype
Control Groups
Cardiovascular System
Gene Frequency
LDL Cholesterol
Diabetes Mellitus
Nitric Oxide
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

T-786 → C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis. / Nakayama, Masafumi; Yasue, Hirofumi; Yoshimura, Michihiro; Shimasaki, Yukio; Ogawa, Hisao; Kugiyama, Kiyotaka; Mizuno, Yuji; Harada, Eisaku; Nakamura, Shota; Ito, Teruhiko; Saito, Yoshihiko; Miyamoto, Yoshihiro; Ogawa, Yoshihiro; Nakao, Kazuwa.

In: American Journal of Cardiology, Vol. 86, No. 6, 15.09.2000, p. 628-634.

Research output: Contribution to journalArticle

Nakayama, M, Yasue, H, Yoshimura, M, Shimasaki, Y, Ogawa, H, Kugiyama, K, Mizuno, Y, Harada, E, Nakamura, S, Ito, T, Saito, Y, Miyamoto, Y, Ogawa, Y & Nakao, K 2000, 'T-786 → C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis', American Journal of Cardiology, vol. 86, no. 6, pp. 628-634. https://doi.org/10.1016/S0002-9149(00)01041-9
Nakayama, Masafumi ; Yasue, Hirofumi ; Yoshimura, Michihiro ; Shimasaki, Yukio ; Ogawa, Hisao ; Kugiyama, Kiyotaka ; Mizuno, Yuji ; Harada, Eisaku ; Nakamura, Shota ; Ito, Teruhiko ; Saito, Yoshihiko ; Miyamoto, Yoshihiro ; Ogawa, Yoshihiro ; Nakao, Kazuwa. / T-786 → C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis. In: American Journal of Cardiology. 2000 ; Vol. 86, No. 6. pp. 628-634.
@article{6b1fe71aef5d412f9a2453f29afcd1b9,
title = "T-786 → C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis",
abstract = "Recently, we discovered a T-786 → C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene that is associated with coronary spasm. The precise mechanism(s) of myocardial infarction (MI), especially without coronary organic stenosis, has not been elucidated, but it seems possible that coronary spasm plays a key role in the mechanism. In this study, we examined the frequency with which the T-786 → C mutation occurred in 359 patients with MI who were compared with 195 controls. In the MI group, the frequency of C/C, C/T, and T/T genotypes was 1{\%}, 22{\%}, and 77{\%}, respectively. In the control group, the frequency of C/C, C/T, and T/T genotypes were 0{\%}, 8{\%}, and 92{\%}, respectively. The frequency of the C allele was significantly higher in the MI group than in the control group (p < 0.001). In the MI group, 30 of 359 patients (8{\%}) with MI had no stenosed vessels angiographically, 158 (44{\%}) had 1 stenosed vessel, 80 (22{\%}) had 2 stenosed vessels, and 91 (25{\%}) exhibited 3 stenosed vessels. Total and low- density lipoprotein cholesterol levels and the incidence of diabetes mellitus increased as the number of stenosed vessels increased (p < 0.01, respectively). The frequency of the T-786 → C mutation was significantly higher in MI patients with no stenosed vessels (50{\%}) than in those with stenosed vessels (p < 0.003). In conclusion, the T-786 → C mutation was strongly associated with MI, especially without coronary arterial stenosis, in Japanese patients. The association may be due to the impaired effects of nitric oxide in the cardiovascular system. (C) 2000 by Excerpta Medica, Inc.",
author = "Masafumi Nakayama and Hirofumi Yasue and Michihiro Yoshimura and Yukio Shimasaki and Hisao Ogawa and Kiyotaka Kugiyama and Yuji Mizuno and Eisaku Harada and Shota Nakamura and Teruhiko Ito and Yoshihiko Saito and Yoshihiro Miyamoto and Yoshihiro Ogawa and Kazuwa Nakao",
year = "2000",
month = "9",
day = "15",
doi = "10.1016/S0002-9149(00)01041-9",
language = "English",
volume = "86",
pages = "628--634",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - T-786 → C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis

AU - Nakayama, Masafumi

AU - Yasue, Hirofumi

AU - Yoshimura, Michihiro

AU - Shimasaki, Yukio

AU - Ogawa, Hisao

AU - Kugiyama, Kiyotaka

AU - Mizuno, Yuji

AU - Harada, Eisaku

AU - Nakamura, Shota

AU - Ito, Teruhiko

AU - Saito, Yoshihiko

AU - Miyamoto, Yoshihiro

AU - Ogawa, Yoshihiro

AU - Nakao, Kazuwa

PY - 2000/9/15

Y1 - 2000/9/15

N2 - Recently, we discovered a T-786 → C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene that is associated with coronary spasm. The precise mechanism(s) of myocardial infarction (MI), especially without coronary organic stenosis, has not been elucidated, but it seems possible that coronary spasm plays a key role in the mechanism. In this study, we examined the frequency with which the T-786 → C mutation occurred in 359 patients with MI who were compared with 195 controls. In the MI group, the frequency of C/C, C/T, and T/T genotypes was 1%, 22%, and 77%, respectively. In the control group, the frequency of C/C, C/T, and T/T genotypes were 0%, 8%, and 92%, respectively. The frequency of the C allele was significantly higher in the MI group than in the control group (p < 0.001). In the MI group, 30 of 359 patients (8%) with MI had no stenosed vessels angiographically, 158 (44%) had 1 stenosed vessel, 80 (22%) had 2 stenosed vessels, and 91 (25%) exhibited 3 stenosed vessels. Total and low- density lipoprotein cholesterol levels and the incidence of diabetes mellitus increased as the number of stenosed vessels increased (p < 0.01, respectively). The frequency of the T-786 → C mutation was significantly higher in MI patients with no stenosed vessels (50%) than in those with stenosed vessels (p < 0.003). In conclusion, the T-786 → C mutation was strongly associated with MI, especially without coronary arterial stenosis, in Japanese patients. The association may be due to the impaired effects of nitric oxide in the cardiovascular system. (C) 2000 by Excerpta Medica, Inc.

AB - Recently, we discovered a T-786 → C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene that is associated with coronary spasm. The precise mechanism(s) of myocardial infarction (MI), especially without coronary organic stenosis, has not been elucidated, but it seems possible that coronary spasm plays a key role in the mechanism. In this study, we examined the frequency with which the T-786 → C mutation occurred in 359 patients with MI who were compared with 195 controls. In the MI group, the frequency of C/C, C/T, and T/T genotypes was 1%, 22%, and 77%, respectively. In the control group, the frequency of C/C, C/T, and T/T genotypes were 0%, 8%, and 92%, respectively. The frequency of the C allele was significantly higher in the MI group than in the control group (p < 0.001). In the MI group, 30 of 359 patients (8%) with MI had no stenosed vessels angiographically, 158 (44%) had 1 stenosed vessel, 80 (22%) had 2 stenosed vessels, and 91 (25%) exhibited 3 stenosed vessels. Total and low- density lipoprotein cholesterol levels and the incidence of diabetes mellitus increased as the number of stenosed vessels increased (p < 0.01, respectively). The frequency of the T-786 → C mutation was significantly higher in MI patients with no stenosed vessels (50%) than in those with stenosed vessels (p < 0.003). In conclusion, the T-786 → C mutation was strongly associated with MI, especially without coronary arterial stenosis, in Japanese patients. The association may be due to the impaired effects of nitric oxide in the cardiovascular system. (C) 2000 by Excerpta Medica, Inc.

UR - http://www.scopus.com/inward/record.url?scp=0034664245&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034664245&partnerID=8YFLogxK

U2 - 10.1016/S0002-9149(00)01041-9

DO - 10.1016/S0002-9149(00)01041-9

M3 - Article

VL - 86

SP - 628

EP - 634

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 6

ER -