Tuberculosis following liver transplantation: Report of a case and review of the literature

Takashi Nishizaki, Katsuhiko Yanaga, Yuji Soejima, Keiji Kishikawa, Kiyoshi Kajiyama, Hideaki Uchiyama, Jun Yatsunami, Nobuyuki Hara, Keizo Sugimachi

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Abstract

We report on a 44-year-old man who developed tuberculosis 4 months after liver transplantation. The diagnosis was confirmed using a polymerase chain reaction (PCR) technique in bronchial alveolar lavage (BAL) fluid, and the patient was successfully treated by reducing his immunosuppression and administering antituberculous drugs. The patient became afebrile 20 days after starting antituberculous therapy and remains well at home. A review of the literature revealed that tuberculosis after liver transplantation is a rare complication with a reported mortality rate of as high as 40%. The mortality is highest for patients who become symptomatic within 3 months after transplantation (83% vs 0%, P < 0.01; Fisher's exact test) and for those with an interval between the initial symptom and diagnosis of more than 2 weeks (71% vs 0%, P < 0.05). Early diagnosis is, therefore, essential for successful resolution of tuberculosis after liver transplantation.

Original languageEnglish
Pages (from-to)589-592
Number of pages4
JournalTransplant International
Volume9
Issue number6
DOIs
Publication statusPublished - Nov 4 1996

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Liver Transplantation
Tuberculosis
Mortality
Bronchoalveolar Lavage Fluid
Immunosuppression
Early Diagnosis
Transplantation
Polymerase Chain Reaction
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Nishizaki, T., Yanaga, K., Soejima, Y., Kishikawa, K., Kajiyama, K., Uchiyama, H., ... Sugimachi, K. (1996). Tuberculosis following liver transplantation: Report of a case and review of the literature. Transplant International, 9(6), 589-592. https://doi.org/10.1007/BF00335560

Tuberculosis following liver transplantation : Report of a case and review of the literature. / Nishizaki, Takashi; Yanaga, Katsuhiko; Soejima, Yuji; Kishikawa, Keiji; Kajiyama, Kiyoshi; Uchiyama, Hideaki; Yatsunami, Jun; Hara, Nobuyuki; Sugimachi, Keizo.

In: Transplant International, Vol. 9, No. 6, 04.11.1996, p. 589-592.

Research output: Contribution to journalArticle

Nishizaki, T, Yanaga, K, Soejima, Y, Kishikawa, K, Kajiyama, K, Uchiyama, H, Yatsunami, J, Hara, N & Sugimachi, K 1996, 'Tuberculosis following liver transplantation: Report of a case and review of the literature', Transplant International, vol. 9, no. 6, pp. 589-592. https://doi.org/10.1007/BF00335560
Nishizaki, Takashi ; Yanaga, Katsuhiko ; Soejima, Yuji ; Kishikawa, Keiji ; Kajiyama, Kiyoshi ; Uchiyama, Hideaki ; Yatsunami, Jun ; Hara, Nobuyuki ; Sugimachi, Keizo. / Tuberculosis following liver transplantation : Report of a case and review of the literature. In: Transplant International. 1996 ; Vol. 9, No. 6. pp. 589-592.
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