Tumor-associated antigen 22-1-1 expression in the uterine cervical squamous neoplasias

Kenzo Sonoda, Tsunehisa Kaku, Toshiharu Kamura, Manabu Nakashima, Takeshi Watanabe, Hitoo Nakano

Research output: Contribution to journalArticle

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Abstract

We have reported that a novel tumor-associated antigen (Ag), 22-1-1, was expressed in cancer cells derived mainly from the uterus and ovary [K. Sonoda et al., Cancer (Phila.), 77: 1501-1509, 1996]. The 22-1-1 Ag existed not only in adenocarcinomas but also in squamous cell carcinomas in the uterine cervix. Here, a relationship between tumor progression and invasion and 22- 1-1 Ag expression was investigated in squamous cell neoplasms of the uterine cervix using immunohistochemical staining. The 22-1-1 Ag was not detected in normal uterine cervix (0 of 10 total cases) and dysplasias (0 of 47 total cases). However, 20% of carcinoma in situ (4 of 20 total cases) and 16.7% of microinvasive carcinomas (2 of 12 total cases) stained positively for 22-1-1 Ag. Moreover, areas depicting microinvasion on histology in uterine cancers (stage Ia) were more strongly stained than carcinoma in situ lesions. 22-1-1 Ag expression was found to be more frequent in invasive squamous cell carcinomas (82.6%; 57 of 69 total cases). The 22-1-1 Ag existed both in the cytoplasm and on the membrane of cancer cells. These findings suggest that 22-1-1 Ag expression might be related to tumor cell progression and invasion in the uterine cervical squamous cell epithelium.

Original languageEnglish
Pages (from-to)1517-1520
Number of pages4
JournalClinical Cancer Research
Volume4
Issue number6
Publication statusPublished - Jun 1 1998

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Neoplasm Antigens
Neoplasms
Cervix Uteri
Uterine Neoplasms
Carcinoma in Situ
Squamous Cell Carcinoma
Squamous Cell Neoplasms
22-1-1 antigen
Ovarian Neoplasms
Histology
Cytoplasm
Adenocarcinoma
Epithelium
Epithelial Cells
Cell Membrane
Staining and Labeling
Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Sonoda, K., Kaku, T., Kamura, T., Nakashima, M., Watanabe, T., & Nakano, H. (1998). Tumor-associated antigen 22-1-1 expression in the uterine cervical squamous neoplasias. Clinical Cancer Research, 4(6), 1517-1520.

Tumor-associated antigen 22-1-1 expression in the uterine cervical squamous neoplasias. / Sonoda, Kenzo; Kaku, Tsunehisa; Kamura, Toshiharu; Nakashima, Manabu; Watanabe, Takeshi; Nakano, Hitoo.

In: Clinical Cancer Research, Vol. 4, No. 6, 01.06.1998, p. 1517-1520.

Research output: Contribution to journalArticle

Sonoda, K, Kaku, T, Kamura, T, Nakashima, M, Watanabe, T & Nakano, H 1998, 'Tumor-associated antigen 22-1-1 expression in the uterine cervical squamous neoplasias', Clinical Cancer Research, vol. 4, no. 6, pp. 1517-1520.
Sonoda K, Kaku T, Kamura T, Nakashima M, Watanabe T, Nakano H. Tumor-associated antigen 22-1-1 expression in the uterine cervical squamous neoplasias. Clinical Cancer Research. 1998 Jun 1;4(6):1517-1520.
Sonoda, Kenzo ; Kaku, Tsunehisa ; Kamura, Toshiharu ; Nakashima, Manabu ; Watanabe, Takeshi ; Nakano, Hitoo. / Tumor-associated antigen 22-1-1 expression in the uterine cervical squamous neoplasias. In: Clinical Cancer Research. 1998 ; Vol. 4, No. 6. pp. 1517-1520.
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