Tumor budding and laminin5-γ2 in squamous cell carcinoma of the external auditory canal are associated with shorter survival

Yasuko Okado, Mikiko Aoki, Makoto Hamasaki, Kaori Koga, Takayuki Sueta, Hideki Shiratsuchi, Yoshinao Oda, Takashi Nakagawa, Kazuki Nabeshima

Research output: Contribution to journalArticle

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Abstract

Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is rare, usually presents at an advanced stage, and is a more aggressive tumor with poor prognosis. The University of Pittsburgh TNM staging system commonly used in prognostication is not perfect, and more accurate biomarkers predicting prognosis are needed. Tumor budding is an established negative prognostic factor at the invasive front in colorectal cancer. Moreover, immunohistochemical studies showed that laminin 5-γ2 (Ln5-γ2) is expressed at the invasive front in tumor or tumor budding cells. We assessed the prognostic significance of tumor budding and Ln5-γ2 expression by performing Ln5-γ2 immunohistochemistry and evaluated the degree of tumor budding in pre-treatment biopsy specimens, and investigated their correlations to clinicopathological parameters in patients with SCC of the EAC. Patients whose tumors had high budding grade and Ln5-γ2 expression had significantly shorter survival times. Budding grade was significantly correlated with Ln5-γ2 expression. Multivariate analysis revealed that high budding grade predicted poorer prognosis regardless of disease stage. Our results suggested that budding grade and Ln5-γ2 expression can be used as indicators of poor prognosis in patients with SCC of the EAC.

Original languageEnglish
Article number814
Pages (from-to)1-11
Number of pages11
JournalSpringerPlus
Volume4
Issue number1
DOIs
Publication statusPublished - Dec 1 2015

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Ear Canal
Squamous Cell Carcinoma
Survival
Neoplasms
Neoplasm Staging
kalinin
Colorectal Neoplasms
Multivariate Analysis
Biomarkers
Immunohistochemistry
Biopsy

All Science Journal Classification (ASJC) codes

  • General

Cite this

Okado, Y., Aoki, M., Hamasaki, M., Koga, K., Sueta, T., Shiratsuchi, H., ... Nabeshima, K. (2015). Tumor budding and laminin5-γ2 in squamous cell carcinoma of the external auditory canal are associated with shorter survival. SpringerPlus, 4(1), 1-11. [814]. https://doi.org/10.1186/s40064-015-1620-4

Tumor budding and laminin5-γ2 in squamous cell carcinoma of the external auditory canal are associated with shorter survival. / Okado, Yasuko; Aoki, Mikiko; Hamasaki, Makoto; Koga, Kaori; Sueta, Takayuki; Shiratsuchi, Hideki; Oda, Yoshinao; Nakagawa, Takashi; Nabeshima, Kazuki.

In: SpringerPlus, Vol. 4, No. 1, 814, 01.12.2015, p. 1-11.

Research output: Contribution to journalArticle

Okado, Yasuko ; Aoki, Mikiko ; Hamasaki, Makoto ; Koga, Kaori ; Sueta, Takayuki ; Shiratsuchi, Hideki ; Oda, Yoshinao ; Nakagawa, Takashi ; Nabeshima, Kazuki. / Tumor budding and laminin5-γ2 in squamous cell carcinoma of the external auditory canal are associated with shorter survival. In: SpringerPlus. 2015 ; Vol. 4, No. 1. pp. 1-11.
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