Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy

Arihiro Kano, Yuki Taniwaki, Izumi Nakamura, Naohiko Shimada, Kenji Moriyama, Atsushi Maruyama

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Photofrin® (porfimer sodium) is a photosensitive reagent used for photodynamic therapy (PDT) of tumors and dysplasias. Because only photo-irradiated sites are damaged, PDT is less invasive than systemic treatments. However, a photosensitive reaction is a major side effect of systemically delivered Photofrin. To enhance localization of Photofrin to tumors, we have formulated Photofrin with the tumor-localizing graft copolymer poly(ethylene glycol)-grafted poly(l-lysine), PLL-g-PEG. We demonstrate that Photofrin preferentially interacts with PLL-g-PEG through both ionic and hydrophobic interactions. The serum competitive study showed that the highly PEG-grafted PLL is better for preventing serum binding to the Photofrin/PLL-g-PEG complex. In tumor-bearing mice, formulation of Photofrin with PLL-g-PEG enhanced tumor localization of Photofrin as twice as Photofrin alone and concomitantly suppressed the photosensitivity reaction drastically.

Original languageEnglish
Pages (from-to)315-321
Number of pages7
JournalJournal of Controlled Release
Volume167
Issue number3
DOIs
Publication statusPublished - May 10 2013

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy'. Together they form a unique fingerprint.

  • Cite this

    Kano, A., Taniwaki, Y., Nakamura, I., Shimada, N., Moriyama, K., & Maruyama, A. (2013). Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy. Journal of Controlled Release, 167(3), 315-321. https://doi.org/10.1016/j.jconrel.2013.02.016