Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy

Arihiro Kano, Yuki Taniwaki, Izumi Nakamura, Naohiko Shimada, Kenji Moriyama, Atsushi Maruyama

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Photofrin® (porfimer sodium) is a photosensitive reagent used for photodynamic therapy (PDT) of tumors and dysplasias. Because only photo-irradiated sites are damaged, PDT is less invasive than systemic treatments. However, a photosensitive reaction is a major side effect of systemically delivered Photofrin. To enhance localization of Photofrin to tumors, we have formulated Photofrin with the tumor-localizing graft copolymer poly(ethylene glycol)-grafted poly(l-lysine), PLL-g-PEG. We demonstrate that Photofrin preferentially interacts with PLL-g-PEG through both ionic and hydrophobic interactions. The serum competitive study showed that the highly PEG-grafted PLL is better for preventing serum binding to the Photofrin/PLL-g-PEG complex. In tumor-bearing mice, formulation of Photofrin with PLL-g-PEG enhanced tumor localization of Photofrin as twice as Photofrin alone and concomitantly suppressed the photosensitivity reaction drastically.

Original languageEnglish
Pages (from-to)315-321
Number of pages7
JournalJournal of Controlled Release
Volume167
Issue number3
DOIs
Publication statusPublished - May 10 2013

Fingerprint

Dihematoporphyrin Ether
Photochemotherapy
Neoplasms
polylysine-graft-(poly(ethylene glycol))
Ethylene Glycol
Serum
Hydrophobic and Hydrophilic Interactions
Lysine

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Kano, A., Taniwaki, Y., Nakamura, I., Shimada, N., Moriyama, K., & Maruyama, A. (2013). Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy. Journal of Controlled Release, 167(3), 315-321. https://doi.org/10.1016/j.jconrel.2013.02.016

Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy. / Kano, Arihiro; Taniwaki, Yuki; Nakamura, Izumi; Shimada, Naohiko; Moriyama, Kenji; Maruyama, Atsushi.

In: Journal of Controlled Release, Vol. 167, No. 3, 10.05.2013, p. 315-321.

Research output: Contribution to journalArticle

Kano, A, Taniwaki, Y, Nakamura, I, Shimada, N, Moriyama, K & Maruyama, A 2013, 'Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy', Journal of Controlled Release, vol. 167, no. 3, pp. 315-321. https://doi.org/10.1016/j.jconrel.2013.02.016
Kano, Arihiro ; Taniwaki, Yuki ; Nakamura, Izumi ; Shimada, Naohiko ; Moriyama, Kenji ; Maruyama, Atsushi. / Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy. In: Journal of Controlled Release. 2013 ; Vol. 167, No. 3. pp. 315-321.
@article{118b7fb289c54ca1a9c0670193293d61,
title = "Tumor delivery of Photofrin{\circledR} by PLL-g-PEG for photodynamic therapy",
abstract = "Photofrin{\circledR} (porfimer sodium) is a photosensitive reagent used for photodynamic therapy (PDT) of tumors and dysplasias. Because only photo-irradiated sites are damaged, PDT is less invasive than systemic treatments. However, a photosensitive reaction is a major side effect of systemically delivered Photofrin. To enhance localization of Photofrin to tumors, we have formulated Photofrin with the tumor-localizing graft copolymer poly(ethylene glycol)-grafted poly(l-lysine), PLL-g-PEG. We demonstrate that Photofrin preferentially interacts with PLL-g-PEG through both ionic and hydrophobic interactions. The serum competitive study showed that the highly PEG-grafted PLL is better for preventing serum binding to the Photofrin/PLL-g-PEG complex. In tumor-bearing mice, formulation of Photofrin with PLL-g-PEG enhanced tumor localization of Photofrin as twice as Photofrin alone and concomitantly suppressed the photosensitivity reaction drastically.",
author = "Arihiro Kano and Yuki Taniwaki and Izumi Nakamura and Naohiko Shimada and Kenji Moriyama and Atsushi Maruyama",
year = "2013",
month = "5",
day = "10",
doi = "10.1016/j.jconrel.2013.02.016",
language = "English",
volume = "167",
pages = "315--321",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy

AU - Kano, Arihiro

AU - Taniwaki, Yuki

AU - Nakamura, Izumi

AU - Shimada, Naohiko

AU - Moriyama, Kenji

AU - Maruyama, Atsushi

PY - 2013/5/10

Y1 - 2013/5/10

N2 - Photofrin® (porfimer sodium) is a photosensitive reagent used for photodynamic therapy (PDT) of tumors and dysplasias. Because only photo-irradiated sites are damaged, PDT is less invasive than systemic treatments. However, a photosensitive reaction is a major side effect of systemically delivered Photofrin. To enhance localization of Photofrin to tumors, we have formulated Photofrin with the tumor-localizing graft copolymer poly(ethylene glycol)-grafted poly(l-lysine), PLL-g-PEG. We demonstrate that Photofrin preferentially interacts with PLL-g-PEG through both ionic and hydrophobic interactions. The serum competitive study showed that the highly PEG-grafted PLL is better for preventing serum binding to the Photofrin/PLL-g-PEG complex. In tumor-bearing mice, formulation of Photofrin with PLL-g-PEG enhanced tumor localization of Photofrin as twice as Photofrin alone and concomitantly suppressed the photosensitivity reaction drastically.

AB - Photofrin® (porfimer sodium) is a photosensitive reagent used for photodynamic therapy (PDT) of tumors and dysplasias. Because only photo-irradiated sites are damaged, PDT is less invasive than systemic treatments. However, a photosensitive reaction is a major side effect of systemically delivered Photofrin. To enhance localization of Photofrin to tumors, we have formulated Photofrin with the tumor-localizing graft copolymer poly(ethylene glycol)-grafted poly(l-lysine), PLL-g-PEG. We demonstrate that Photofrin preferentially interacts with PLL-g-PEG through both ionic and hydrophobic interactions. The serum competitive study showed that the highly PEG-grafted PLL is better for preventing serum binding to the Photofrin/PLL-g-PEG complex. In tumor-bearing mice, formulation of Photofrin with PLL-g-PEG enhanced tumor localization of Photofrin as twice as Photofrin alone and concomitantly suppressed the photosensitivity reaction drastically.

UR - http://www.scopus.com/inward/record.url?scp=84875043582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875043582&partnerID=8YFLogxK

U2 - 10.1016/j.jconrel.2013.02.016

DO - 10.1016/j.jconrel.2013.02.016

M3 - Article

C2 - 23454112

AN - SCOPUS:84875043582

VL - 167

SP - 315

EP - 321

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

IS - 3

ER -