Tumor doubling time of renal cell carcinoma measured by CT: Collaboration of Japanese Society of Renal Cancer

Seiichiro Ozono; Noriomi Miyao; Tatsuo Igarashi; Ken Marumo; Hayakazu Nakazawa; Momokuni Fukuda; Tomoyasu Tsushima; Noriaki Tokuda; Juichi Kawamura; Masaru Murai; Masatoshi Eto; Michihiko Hasegawa; Masamichi Hayakawa; Shigeo Horie; Yukio Homma; Shigeo Isaka; Go Kimura; Mikio Kobayashi; Osamu Matsuzaki; Masahiro Nakao; Takahisa Nakamoto; Yoji Nagashima; Satoshi Nagamori; Norio Nonomura; Tetsuro Onishi; Hiroomi Kanayama; Yutaka Senga; Toshiro Terachi; Yoshihiko Tomita; Makoto Yanagawa

doi:10.1093/jjco/hyh011

Tumor doubling time of renal cell carcinoma measured by CT: Collaboration of Japanese Society of Renal Cancer

Seiichiro Ozono, Noriomi Miyao, Tatsuo Igarashi, Ken Marumo, Hayakazu Nakazawa, Momokuni Fukuda, Tomoyasu Tsushima, Noriaki Tokuda, Juichi Kawamura, Masaru Murai, Masatoshi Eto, Michihiko Hasegawa, Masamichi Hayakawa, Shigeo Horie, Yukio Homma, Shigeo Isaka, Go Kimura, Mikio Kobayashi, Osamu Matsuzaki, Masahiro NakaoTakahisa Nakamoto, Yoji Nagashima, Satoshi Nagamori, Norio Nonomura, Tetsuro Onishi, Hiroomi Kanayama, Yutaka Senga, Toshiro Terachi, Yoshihiko Tomita, Makoto Yanagawa

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Abstract

Objective: This study was conducted to examine the natural history of renal cell carcinoma (RCC). Methods: Inclusion criteria were the following: (1) patients who received diagnostic imaging of the kidney (CT, MRI) at two points in time before the diagnosis of RCC or patients who were followed, without treatment, after a diagnosis of RCC; and (2) patients in whom changes in tumor size were followed by the same modality of diagnostic imaging and who did not receive any treatment which could exert anti-tumor activity on the primary or metastatic lesions. The tumor doubling time (DT) and the growth rate of maximum tumor diameter (R) were determined. DT was calculated using the equation DT = (T - T₀) × log2/logV - logV₀ (where T - T₀ indicates the length of time between two measurements and V₀ and V denote the tumor volume at two points of measurement). R was calculated using the equation R = (φ - f₀)/(T - T₀) × 100 (where φ₀ and f indicate the maximum diameter at two points). Fifty-six cases registered with the Japanese Society of Renal Cancer were included in the evaluation. Results: DT was 603.1 ± 510.1 days, which did not correlate with V₀. R was 0.263 ± 0.346 cm/day × 100. In cases where the tumor diameter was ≥4 cm, a significant correlation was noted between f₀ and R. Conclusions: Elucidation of the natural history of RCC will contribute to facilitation of differential diagnosis and determination of optimum therapeutic strategy.

Original language	English
Pages (from-to)	82-85
Number of pages	4
Journal	Japanese journal of clinical oncology
Volume	34
Issue number	2
DOIs	https://doi.org/10.1093/jjco/hyh011
Publication status	Published - Feb 1 2004

All Science Journal Classification (ASJC) codes

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jjco/hyh011

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Ozono, S., Miyao, N., Igarashi, T., Marumo, K., Nakazawa, H., Fukuda, M., Tsushima, T., Tokuda, N., Kawamura, J., Murai, M., Eto, M., Hasegawa, M., Hayakawa, M., Horie, S., Homma, Y., Isaka, S., Kimura, G., Kobayashi, M., Matsuzaki, O., ... Yanagawa, M. (2004). Tumor doubling time of renal cell carcinoma measured by CT: Collaboration of Japanese Society of Renal Cancer. Japanese journal of clinical oncology, 34(2), 82-85. https://doi.org/10.1093/jjco/hyh011

Ozono, S, Miyao, N, Igarashi, T, Marumo, K, Nakazawa, H, Fukuda, M, Tsushima, T, Tokuda, N, Kawamura, J, Murai, M, Eto, M, Hasegawa, M, Hayakawa, M, Horie, S, Homma, Y, Isaka, S, Kimura, G, Kobayashi, M, Matsuzaki, O, Nakao, M, Nakamoto, T, Nagashima, Y, Nagamori, S, Nonomura, N, Onishi, T, Kanayama, H, Senga, Y, Terachi, T, Tomita, Y & Yanagawa, M 2004, 'Tumor doubling time of renal cell carcinoma measured by CT: Collaboration of Japanese Society of Renal Cancer', Japanese journal of clinical oncology, vol. 34, no. 2, pp. 82-85. https://doi.org/10.1093/jjco/hyh011

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title = "Tumor doubling time of renal cell carcinoma measured by CT: Collaboration of Japanese Society of Renal Cancer",

abstract = "Objective: This study was conducted to examine the natural history of renal cell carcinoma (RCC). Methods: Inclusion criteria were the following: (1) patients who received diagnostic imaging of the kidney (CT, MRI) at two points in time before the diagnosis of RCC or patients who were followed, without treatment, after a diagnosis of RCC; and (2) patients in whom changes in tumor size were followed by the same modality of diagnostic imaging and who did not receive any treatment which could exert anti-tumor activity on the primary or metastatic lesions. The tumor doubling time (DT) and the growth rate of maximum tumor diameter (R) were determined. DT was calculated using the equation DT = (T - T0) × log2/logV - logV0 (where T - T0 indicates the length of time between two measurements and V0 and V denote the tumor volume at two points of measurement). R was calculated using the equation R = (φ - f0)/(T - T0) × 100 (where φ0 and f indicate the maximum diameter at two points). Fifty-six cases registered with the Japanese Society of Renal Cancer were included in the evaluation. Results: DT was 603.1 ± 510.1 days, which did not correlate with V0. R was 0.263 ± 0.346 cm/day × 100. In cases where the tumor diameter was ≥4 cm, a significant correlation was noted between f0 and R. Conclusions: Elucidation of the natural history of RCC will contribute to facilitation of differential diagnosis and determination of optimum therapeutic strategy.",

author = "Seiichiro Ozono and Noriomi Miyao and Tatsuo Igarashi and Ken Marumo and Hayakazu Nakazawa and Momokuni Fukuda and Tomoyasu Tsushima and Noriaki Tokuda and Juichi Kawamura and Masaru Murai and Masatoshi Eto and Michihiko Hasegawa and Masamichi Hayakawa and Shigeo Horie and Yukio Homma and Shigeo Isaka and Go Kimura and Mikio Kobayashi and Osamu Matsuzaki and Masahiro Nakao and Takahisa Nakamoto and Yoji Nagashima and Satoshi Nagamori and Norio Nonomura and Tetsuro Onishi and Hiroomi Kanayama and Yutaka Senga and Toshiro Terachi and Yoshihiko Tomita and Makoto Yanagawa",

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doi = "10.1093/jjco/hyh011",

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T1 - Tumor doubling time of renal cell carcinoma measured by CT

T2 - Collaboration of Japanese Society of Renal Cancer

AU - Ozono, Seiichiro

AU - Miyao, Noriomi

AU - Igarashi, Tatsuo

AU - Marumo, Ken

AU - Nakazawa, Hayakazu

AU - Fukuda, Momokuni

AU - Tsushima, Tomoyasu

AU - Tokuda, Noriaki

AU - Kawamura, Juichi

AU - Murai, Masaru

AU - Eto, Masatoshi

AU - Hasegawa, Michihiko

AU - Hayakawa, Masamichi

AU - Horie, Shigeo

AU - Homma, Yukio

AU - Isaka, Shigeo

AU - Kimura, Go

AU - Kobayashi, Mikio

AU - Matsuzaki, Osamu

AU - Nakao, Masahiro

AU - Nakamoto, Takahisa

AU - Nagashima, Yoji

AU - Nagamori, Satoshi

AU - Nonomura, Norio

AU - Onishi, Tetsuro

AU - Kanayama, Hiroomi

AU - Senga, Yutaka

AU - Terachi, Toshiro

AU - Tomita, Yoshihiko

AU - Yanagawa, Makoto

PY - 2004/2/1

Y1 - 2004/2/1

N2 - Objective: This study was conducted to examine the natural history of renal cell carcinoma (RCC). Methods: Inclusion criteria were the following: (1) patients who received diagnostic imaging of the kidney (CT, MRI) at two points in time before the diagnosis of RCC or patients who were followed, without treatment, after a diagnosis of RCC; and (2) patients in whom changes in tumor size were followed by the same modality of diagnostic imaging and who did not receive any treatment which could exert anti-tumor activity on the primary or metastatic lesions. The tumor doubling time (DT) and the growth rate of maximum tumor diameter (R) were determined. DT was calculated using the equation DT = (T - T0) × log2/logV - logV0 (where T - T0 indicates the length of time between two measurements and V0 and V denote the tumor volume at two points of measurement). R was calculated using the equation R = (φ - f0)/(T - T0) × 100 (where φ0 and f indicate the maximum diameter at two points). Fifty-six cases registered with the Japanese Society of Renal Cancer were included in the evaluation. Results: DT was 603.1 ± 510.1 days, which did not correlate with V0. R was 0.263 ± 0.346 cm/day × 100. In cases where the tumor diameter was ≥4 cm, a significant correlation was noted between f0 and R. Conclusions: Elucidation of the natural history of RCC will contribute to facilitation of differential diagnosis and determination of optimum therapeutic strategy.

AB - Objective: This study was conducted to examine the natural history of renal cell carcinoma (RCC). Methods: Inclusion criteria were the following: (1) patients who received diagnostic imaging of the kidney (CT, MRI) at two points in time before the diagnosis of RCC or patients who were followed, without treatment, after a diagnosis of RCC; and (2) patients in whom changes in tumor size were followed by the same modality of diagnostic imaging and who did not receive any treatment which could exert anti-tumor activity on the primary or metastatic lesions. The tumor doubling time (DT) and the growth rate of maximum tumor diameter (R) were determined. DT was calculated using the equation DT = (T - T0) × log2/logV - logV0 (where T - T0 indicates the length of time between two measurements and V0 and V denote the tumor volume at two points of measurement). R was calculated using the equation R = (φ - f0)/(T - T0) × 100 (where φ0 and f indicate the maximum diameter at two points). Fifty-six cases registered with the Japanese Society of Renal Cancer were included in the evaluation. Results: DT was 603.1 ± 510.1 days, which did not correlate with V0. R was 0.263 ± 0.346 cm/day × 100. In cases where the tumor diameter was ≥4 cm, a significant correlation was noted between f0 and R. Conclusions: Elucidation of the natural history of RCC will contribute to facilitation of differential diagnosis and determination of optimum therapeutic strategy.

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Tumor doubling time of renal cell carcinoma measured by CT: Collaboration of Japanese Society of Renal Cancer

Abstract

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