TY - JOUR
T1 - Tumor enhancement on dynamic CT
T2 - A predictive factor for recurrence after nephrectomy in localized T1 clear cell renal cell carcinoma
AU - Maehara, Junki
AU - Nishie, Akihiro
AU - Asayama, Yoshiki
AU - Ishigami, Kousei
AU - Ushijima, Yasuhiro
AU - Takayama, Yukihisa
AU - Okamoto, Daisuke
AU - Fujita, Nobuhiro
AU - Sugimoto, Masaaki
AU - Inokuchi, Junichi
AU - Honda, Hiroshi
N1 - Funding Information:
The Authors thank Professor Yoshinao Oda, Department of Anatomic Pathology, Kyushu University, for providing the pathological information and Professor Masatoshi Eto, Department of Urology, Kyushu University, for providing the clinical information.
Publisher Copyright:
© 2018 International Institute of Anticancer Research. All Rights Reserved.
PY - 2018/4
Y1 - 2018/4
N2 - Aim: To investigate whether radiological parameters obtained on dynamic computed tomography (CT), especially those related to tumor enhancement, are predictive factors for recurrence after nephrectomy in localized stage T1 clear cell renal cell carcinoma (ccRCC). Materials and Methods: We retrospectively studied 88 patients with localized stage T1 ccRCC who underwent dynamic CT preoperatively. Seven patients had recurrent disease after surgery. Tumor attenuations were measured by placing a region of interest in the solid region. TApre and TAneph were defined as the tumor attenuation values of the pre-contrast and nephrographic phase, respectively. The correlations between disease-free survival and clinicopathological factors, including the radiological parameter TAneph – TApre (ΔTAneph), were analyzed by Cox proportional hazards model or Kaplan–Meier method with the log-rank test. Results: Only ΔTAneph was significantly and positively correlated with disease-free survival (p<0.05). Tumor size also tended to be negatively correlated with disease-free survival (p<0.1). The 5- and 10-year disease-free survival rates of the group with high ΔTAneph (≥86 HU) were 97.4% and 97.4%, while those of the group with low ΔTAneph (<86 HU) were 89.6% and 71.6%, respectively. Conclusion: Tumor enhancement in the nephrographic phase of CT was a predictive factor for recurrence after nephrectomy in patients with localized stage T1 ccRCC.
AB - Aim: To investigate whether radiological parameters obtained on dynamic computed tomography (CT), especially those related to tumor enhancement, are predictive factors for recurrence after nephrectomy in localized stage T1 clear cell renal cell carcinoma (ccRCC). Materials and Methods: We retrospectively studied 88 patients with localized stage T1 ccRCC who underwent dynamic CT preoperatively. Seven patients had recurrent disease after surgery. Tumor attenuations were measured by placing a region of interest in the solid region. TApre and TAneph were defined as the tumor attenuation values of the pre-contrast and nephrographic phase, respectively. The correlations between disease-free survival and clinicopathological factors, including the radiological parameter TAneph – TApre (ΔTAneph), were analyzed by Cox proportional hazards model or Kaplan–Meier method with the log-rank test. Results: Only ΔTAneph was significantly and positively correlated with disease-free survival (p<0.05). Tumor size also tended to be negatively correlated with disease-free survival (p<0.1). The 5- and 10-year disease-free survival rates of the group with high ΔTAneph (≥86 HU) were 97.4% and 97.4%, while those of the group with low ΔTAneph (<86 HU) were 89.6% and 71.6%, respectively. Conclusion: Tumor enhancement in the nephrographic phase of CT was a predictive factor for recurrence after nephrectomy in patients with localized stage T1 ccRCC.
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U2 - 10.21873/anticanres.12486
DO - 10.21873/anticanres.12486
M3 - Article
C2 - 29599364
AN - SCOPUS:85045090094
SN - 0250-7005
VL - 38
SP - 2377
EP - 2383
JO - Anticancer Research
JF - Anticancer Research
IS - 4
ER -
