Abstract
We report a case of tumor-induced osteomalacia (TIO) caused by a massive phosphaturic mesenchymal tumor (PMT) of the acetabulum. A 68-year-old woman presented with progressive bone pain of the rib cage, and polyarthralgia and back pain for 3 years. She was diagnosed with hypophosphatemic osteomalacia because laboratory testing was remarkable for low serum phosphorus and a low level of 1,25(OH)2 vitamin D. Three years later, her hip radiograph revealed an osteolytic lesion of the acetabulum. Magnetic resonance imaging of the acetabulum showed a massive lesion. Laboratory data showed hypophosphatemia and an elevated serum level of fibroblast growth factor 23 (FGF-23). Samples obtained with open biopsy showed a low-grade spindle cell neoplasm with FGF-23 positivity, identified by using immunohistochemical staining, confirming the diagnosis of a PMT mixed connective tissue variant. Curettage of the tumor was performed, and the defects were filled with bone allografts. The hip joint was reconstructed with total hip arthroplasty using a Muller support ring. To our knowledge, this report represents the first documented case of massive PMT of the acetabulum causing TIO.
| Original language | English |
|---|---|
| Pages (from-to) | 906-910 |
| Number of pages | 5 |
| Journal | Modern Rheumatology |
| Volume | 28 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Sep 3 2018 |
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All Science Journal Classification (ASJC) codes
- Rheumatology
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Tumor-induced osteomalacia caused by a massive phosphaturic mesenchymal tumor of the acetabulum : A case report. / Nakamura, Kimitaka; Ohishi, Masanobu; Matsunobu, Tomoya; Nakashima, Yasuharu; Sakamoto, Akio; Maekawa, Akira; Oda, Yoshinao; Iwamoto, Yukihide.
In: Modern Rheumatology, Vol. 28, No. 5, 03.09.2018, p. 906-910.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tumor-induced osteomalacia caused by a massive phosphaturic mesenchymal tumor of the acetabulum
T2 - A case report
AU - Nakamura, Kimitaka
AU - Ohishi, Masanobu
AU - Matsunobu, Tomoya
AU - Nakashima, Yasuharu
AU - Sakamoto, Akio
AU - Maekawa, Akira
AU - Oda, Yoshinao
AU - Iwamoto, Yukihide
PY - 2018/9/3
Y1 - 2018/9/3
N2 - We report a case of tumor-induced osteomalacia (TIO) caused by a massive phosphaturic mesenchymal tumor (PMT) of the acetabulum. A 68-year-old woman presented with progressive bone pain of the rib cage, and polyarthralgia and back pain for 3 years. She was diagnosed with hypophosphatemic osteomalacia because laboratory testing was remarkable for low serum phosphorus and a low level of 1,25(OH)2 vitamin D. Three years later, her hip radiograph revealed an osteolytic lesion of the acetabulum. Magnetic resonance imaging of the acetabulum showed a massive lesion. Laboratory data showed hypophosphatemia and an elevated serum level of fibroblast growth factor 23 (FGF-23). Samples obtained with open biopsy showed a low-grade spindle cell neoplasm with FGF-23 positivity, identified by using immunohistochemical staining, confirming the diagnosis of a PMT mixed connective tissue variant. Curettage of the tumor was performed, and the defects were filled with bone allografts. The hip joint was reconstructed with total hip arthroplasty using a Muller support ring. To our knowledge, this report represents the first documented case of massive PMT of the acetabulum causing TIO.
AB - We report a case of tumor-induced osteomalacia (TIO) caused by a massive phosphaturic mesenchymal tumor (PMT) of the acetabulum. A 68-year-old woman presented with progressive bone pain of the rib cage, and polyarthralgia and back pain for 3 years. She was diagnosed with hypophosphatemic osteomalacia because laboratory testing was remarkable for low serum phosphorus and a low level of 1,25(OH)2 vitamin D. Three years later, her hip radiograph revealed an osteolytic lesion of the acetabulum. Magnetic resonance imaging of the acetabulum showed a massive lesion. Laboratory data showed hypophosphatemia and an elevated serum level of fibroblast growth factor 23 (FGF-23). Samples obtained with open biopsy showed a low-grade spindle cell neoplasm with FGF-23 positivity, identified by using immunohistochemical staining, confirming the diagnosis of a PMT mixed connective tissue variant. Curettage of the tumor was performed, and the defects were filled with bone allografts. The hip joint was reconstructed with total hip arthroplasty using a Muller support ring. To our knowledge, this report represents the first documented case of massive PMT of the acetabulum causing TIO.
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UR - http://www.scopus.com/inward/citedby.url?scp=84965028122&partnerID=8YFLogxK
U2 - 10.3109/14397595.2016.1173322
DO - 10.3109/14397595.2016.1173322
M3 - Article
C2 - 27141918
AN - SCOPUS:84965028122
VL - 28
SP - 906
EP - 910
JO - Modern Rheumatology
JF - Modern Rheumatology
SN - 1439-7595
IS - 5
ER -