TY - JOUR
T1 - Tumor-infiltrating lymphocytes and hepatocellular carcinoma
T2 - Pathology and clinical management
AU - Shirabe, Ken
AU - Motomura, Takashi
AU - Muto, Jun
AU - Toshima, Takeo
AU - Matono, Rumi
AU - Mano, Yohei
AU - takeishi, kazuki
AU - Ijichi, Hideki
AU - Harada, Noboru
AU - Uchiyama, Hideaki
AU - Yoshizumi, Tomoharu
AU - Taketomi, Akinobu
AU - Maehara, Yoshihiko
PY - 2010/12
Y1 - 2010/12
N2 - The presence of tumor-infiltrating lymphocytes (TILs) in hepatocellular carcinoma (HCC) is relatively rare. The prognosis of patients with HCC and marked TILs is better than that of patients with HCC without TILs. TILs in HCC tissues are mainly T cells, and previous reports suggested that TILs might be important antitumor effector cells. TILs have been extensively analyzed, and subpopulations of CD3+, CD4+, and CD8+ T cells are often present in HCC. Some studies have reported that the percentage of CD8+ T cells, which might have cytotoxic activity, is decreased in tumors with TILs, as compared with noncancerous tissues. Although the antitumor effects of TILs seem to be impaired in HCCs, the underlying mechanism has remained unclear until quite recently. Pathological and in vitro studies have now shown that regulatory T cells play important roles in the deterioration of the antitumor effects of TILs. The aim of this review is to introduce recent pathological findings for TILs in HCC and to evaluate new therapeutic strategies in this field.
AB - The presence of tumor-infiltrating lymphocytes (TILs) in hepatocellular carcinoma (HCC) is relatively rare. The prognosis of patients with HCC and marked TILs is better than that of patients with HCC without TILs. TILs in HCC tissues are mainly T cells, and previous reports suggested that TILs might be important antitumor effector cells. TILs have been extensively analyzed, and subpopulations of CD3+, CD4+, and CD8+ T cells are often present in HCC. Some studies have reported that the percentage of CD8+ T cells, which might have cytotoxic activity, is decreased in tumors with TILs, as compared with noncancerous tissues. Although the antitumor effects of TILs seem to be impaired in HCCs, the underlying mechanism has remained unclear until quite recently. Pathological and in vitro studies have now shown that regulatory T cells play important roles in the deterioration of the antitumor effects of TILs. The aim of this review is to introduce recent pathological findings for TILs in HCC and to evaluate new therapeutic strategies in this field.
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U2 - 10.1007/s10147-010-0131-0
DO - 10.1007/s10147-010-0131-0
M3 - Article
C2 - 20963618
AN - SCOPUS:78651073261
VL - 15
SP - 552
EP - 558
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
SN - 1341-9625
IS - 6
ER -