Tumor invasion and angiogenesis in early esophageal squamous cell carcinoma

Hiroyuki Kuwano, Kozo Sonoda, Mitsuhiro Yasuda, Kohei Sumiyoshi, Tadahiro Nozoe, Keizo Sugimachi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background and Objectives: Although the relationship between angiogenesis and tumor proliferation or malignant potential has been previously demonstrated in several studies, early stage of cancer invasion and angiogenesis has seldom been investigated. Methods: From the esophageal specimens of eight recently resected cases with esophageal squamous cell carcinoma, 25 areas of carcinoma-in-situ or microinvasive carcinoma were selected, and then a serial histologic investigation and immunohistochemical staining for the detection of Factor VIII-related antigen to investigate microvessels in the lamina propria mucosae beneath the lesions as a measure of angiogeneses and staining for laminin to visualize basement membrane was performed. Lymphocyte infiltration below the lesions were also estimated. In view of early cancerous invasion, histologic patterns of the growth of the lesions were divided into 'flat,' 'expansive,' and 'downgrowth' patterns. Results: Although downgrowth patterns are thought to be more invasive, relationships between the histologic patterns, and basement membrane staining patterns, and lymphocyte infiltration patterns were not demon strated. However, the angiogenetic ratio (the number of vessels/cm under the lesions divided by that under normal epithelium) was observed to be significantly and closely related to tumor invasion patterns (P < 0.01), although it was not related to the destruction of the basement membrane or lymphocyte infiltration below the lesions. Conclusions: The anglogenesis of esophageal squamous cell carcinoma is closely correlated to the tumor invasion patterns in early esophageal can cerous lesions.

Original languageEnglish
Pages (from-to)188-193
Number of pages6
JournalJournal of Surgical Oncology
Volume65
Issue number3
DOIs
Publication statusPublished - Jul 1 1997

Fingerprint

Basement Membrane
Lymphocytes
Staining and Labeling
Neoplasms
Mucous Membrane
Carcinoma in Situ
von Willebrand Factor
Laminin
Microvessels
Epithelium
Carcinoma
Esophageal Squamous Cell Carcinoma
Growth

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Tumor invasion and angiogenesis in early esophageal squamous cell carcinoma. / Kuwano, Hiroyuki; Sonoda, Kozo; Yasuda, Mitsuhiro; Sumiyoshi, Kohei; Nozoe, Tadahiro; Sugimachi, Keizo.

In: Journal of Surgical Oncology, Vol. 65, No. 3, 01.07.1997, p. 188-193.

Research output: Contribution to journalArticle

Kuwano, Hiroyuki ; Sonoda, Kozo ; Yasuda, Mitsuhiro ; Sumiyoshi, Kohei ; Nozoe, Tadahiro ; Sugimachi, Keizo. / Tumor invasion and angiogenesis in early esophageal squamous cell carcinoma. In: Journal of Surgical Oncology. 1997 ; Vol. 65, No. 3. pp. 188-193.
@article{6ca42df6e8a04a4c901c19690351dffb,
title = "Tumor invasion and angiogenesis in early esophageal squamous cell carcinoma",
abstract = "Background and Objectives: Although the relationship between angiogenesis and tumor proliferation or malignant potential has been previously demonstrated in several studies, early stage of cancer invasion and angiogenesis has seldom been investigated. Methods: From the esophageal specimens of eight recently resected cases with esophageal squamous cell carcinoma, 25 areas of carcinoma-in-situ or microinvasive carcinoma were selected, and then a serial histologic investigation and immunohistochemical staining for the detection of Factor VIII-related antigen to investigate microvessels in the lamina propria mucosae beneath the lesions as a measure of angiogeneses and staining for laminin to visualize basement membrane was performed. Lymphocyte infiltration below the lesions were also estimated. In view of early cancerous invasion, histologic patterns of the growth of the lesions were divided into 'flat,' 'expansive,' and 'downgrowth' patterns. Results: Although downgrowth patterns are thought to be more invasive, relationships between the histologic patterns, and basement membrane staining patterns, and lymphocyte infiltration patterns were not demon strated. However, the angiogenetic ratio (the number of vessels/cm under the lesions divided by that under normal epithelium) was observed to be significantly and closely related to tumor invasion patterns (P < 0.01), although it was not related to the destruction of the basement membrane or lymphocyte infiltration below the lesions. Conclusions: The anglogenesis of esophageal squamous cell carcinoma is closely correlated to the tumor invasion patterns in early esophageal can cerous lesions.",
author = "Hiroyuki Kuwano and Kozo Sonoda and Mitsuhiro Yasuda and Kohei Sumiyoshi and Tadahiro Nozoe and Keizo Sugimachi",
year = "1997",
month = "7",
day = "1",
doi = "10.1002/(SICI)1096-9098(199707)65:3<188::AID-JSO8>3.0.CO;2-2",
language = "English",
volume = "65",
pages = "188--193",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Tumor invasion and angiogenesis in early esophageal squamous cell carcinoma

AU - Kuwano, Hiroyuki

AU - Sonoda, Kozo

AU - Yasuda, Mitsuhiro

AU - Sumiyoshi, Kohei

AU - Nozoe, Tadahiro

AU - Sugimachi, Keizo

PY - 1997/7/1

Y1 - 1997/7/1

N2 - Background and Objectives: Although the relationship between angiogenesis and tumor proliferation or malignant potential has been previously demonstrated in several studies, early stage of cancer invasion and angiogenesis has seldom been investigated. Methods: From the esophageal specimens of eight recently resected cases with esophageal squamous cell carcinoma, 25 areas of carcinoma-in-situ or microinvasive carcinoma were selected, and then a serial histologic investigation and immunohistochemical staining for the detection of Factor VIII-related antigen to investigate microvessels in the lamina propria mucosae beneath the lesions as a measure of angiogeneses and staining for laminin to visualize basement membrane was performed. Lymphocyte infiltration below the lesions were also estimated. In view of early cancerous invasion, histologic patterns of the growth of the lesions were divided into 'flat,' 'expansive,' and 'downgrowth' patterns. Results: Although downgrowth patterns are thought to be more invasive, relationships between the histologic patterns, and basement membrane staining patterns, and lymphocyte infiltration patterns were not demon strated. However, the angiogenetic ratio (the number of vessels/cm under the lesions divided by that under normal epithelium) was observed to be significantly and closely related to tumor invasion patterns (P < 0.01), although it was not related to the destruction of the basement membrane or lymphocyte infiltration below the lesions. Conclusions: The anglogenesis of esophageal squamous cell carcinoma is closely correlated to the tumor invasion patterns in early esophageal can cerous lesions.

AB - Background and Objectives: Although the relationship between angiogenesis and tumor proliferation or malignant potential has been previously demonstrated in several studies, early stage of cancer invasion and angiogenesis has seldom been investigated. Methods: From the esophageal specimens of eight recently resected cases with esophageal squamous cell carcinoma, 25 areas of carcinoma-in-situ or microinvasive carcinoma were selected, and then a serial histologic investigation and immunohistochemical staining for the detection of Factor VIII-related antigen to investigate microvessels in the lamina propria mucosae beneath the lesions as a measure of angiogeneses and staining for laminin to visualize basement membrane was performed. Lymphocyte infiltration below the lesions were also estimated. In view of early cancerous invasion, histologic patterns of the growth of the lesions were divided into 'flat,' 'expansive,' and 'downgrowth' patterns. Results: Although downgrowth patterns are thought to be more invasive, relationships between the histologic patterns, and basement membrane staining patterns, and lymphocyte infiltration patterns were not demon strated. However, the angiogenetic ratio (the number of vessels/cm under the lesions divided by that under normal epithelium) was observed to be significantly and closely related to tumor invasion patterns (P < 0.01), although it was not related to the destruction of the basement membrane or lymphocyte infiltration below the lesions. Conclusions: The anglogenesis of esophageal squamous cell carcinoma is closely correlated to the tumor invasion patterns in early esophageal can cerous lesions.

UR - http://www.scopus.com/inward/record.url?scp=0030795398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030795398&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1096-9098(199707)65:3<188::AID-JSO8>3.0.CO;2-2

DO - 10.1002/(SICI)1096-9098(199707)65:3<188::AID-JSO8>3.0.CO;2-2

M3 - Article

C2 - 9236928

AN - SCOPUS:0030795398

VL - 65

SP - 188

EP - 193

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 3

ER -