Tumor necrosis factor in the cerebrospinal fluid of children with central nervous system leukemia

Eiichi Ishii, Shouichi Ohga, Ichirou Murano, Masao Kobayashi, Ken Kimura, Haruhiko Eguchi, Kouhei Akazawa, Kohji Ueda

Research output: Contribution to journalArticle

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Abstract

To clarify the role of cytokines in cerebrospinal fluid (CSF) in the pathogenesis of central nervous system (CNS) leukemia, three cytokine activities, interleukin 1 (IL-1)-beta, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, and their correlations with other laboratory studies of the CSF were analysed in 23 children with acute leukemia. These patients were classified into three groups: group A (n = 8)-patients with overt CNS leukemia, group B (n = 5)-patients with CNS leukemia in remission, group C (n = 10)-patients without CNS disease. IFN-gamma in the CSF was undetectable in these 23 patients. There was no difference in IL-1-beta levels among the three groups. However, TNF-alpha levels were significantly higher in group A than in group B, and higher in group B than in group C. By Kendall's rank sum test, high TNF levels in CSF correlated with high CSF leukemic cell counts and low sugar levels. In two patients with overt CNS leukemia, the TNF level in the CSF decreased gradually with intrathecal chemotherapy. These results indicate that TNF released from stimulated cells in the cerebrospinal space may induce CNS leukemia-related symptoms or alter laboratory parameters measured in the CSF. TNF levels in CSF may also prove useful in diagnosing early CNS involvement in children with acute leukemia.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalLeukemia Research
Volume15
Issue number2-3
DOIs
Publication statusPublished - 1991

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Cerebrospinal Fluid
Leukemia
Central Nervous System
Tumor Necrosis Factor-alpha
Interleukin-1beta
Interferon-gamma
Cytokines
Central Nervous System Diseases
Nonparametric Statistics
Interferon-alpha
Cell Count
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Tumor necrosis factor in the cerebrospinal fluid of children with central nervous system leukemia. / Ishii, Eiichi; Ohga, Shouichi; Murano, Ichirou; Kobayashi, Masao; Kimura, Ken; Eguchi, Haruhiko; Akazawa, Kouhei; Ueda, Kohji.

In: Leukemia Research, Vol. 15, No. 2-3, 1991, p. 143-147.

Research output: Contribution to journalArticle

Ishii, E, Ohga, S, Murano, I, Kobayashi, M, Kimura, K, Eguchi, H, Akazawa, K & Ueda, K 1991, 'Tumor necrosis factor in the cerebrospinal fluid of children with central nervous system leukemia', Leukemia Research, vol. 15, no. 2-3, pp. 143-147. https://doi.org/10.1016/0145-2126(91)90095-B
Ishii, Eiichi ; Ohga, Shouichi ; Murano, Ichirou ; Kobayashi, Masao ; Kimura, Ken ; Eguchi, Haruhiko ; Akazawa, Kouhei ; Ueda, Kohji. / Tumor necrosis factor in the cerebrospinal fluid of children with central nervous system leukemia. In: Leukemia Research. 1991 ; Vol. 15, No. 2-3. pp. 143-147.
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