Tumor tissue is more sensitive to mitomycin C, carboquone, and aclacinomycin A than is adjacent normal tissue in vitro

Yoshihiko Maehara, Hiroki Kusumoto, Tetsuya Kusumoto, Hideaki Anai, Keizo Sugimachi

Research output: Contribution to journalArticle

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Abstract

In tissues obtained from patients undergoing gastrectomy or colectomy, sensitivity to mitomycin C (MMC), carboquone (CQ), and aclacinomycin A (ACR) was examined in 20 tumors (15 gastric, 5 colorectal) and in the adjacent normal mucosal tissues, using the in vitro succinate dehydrogenase inhibition test. The succinate dehydrogenase (SD) activity decreased to a greater extent in the tumor tissues than in adjacent normal tissues, at rates of 80% for MMC, 80% for CQ, and 90% for ACR. There were no correlations between SD activities of tumor and adjacent normal tissue, r = 0.157 for MMC, r = 0.435 for CQ, and r = 0.375 for ACR. Normal tissues were sensitive to MMC in 25 % of cases sensitive to MMC in the tumor tissues, 46% for CQ, and 38% for ACR. These results show that the antitumor effects of MMC, CQ, and ACR are relatively specific for tumor tissues and that the assay of chemosensitivity of normal tissues is meaningful for predicting the toxic effects of antitumor drugs on these tissues.

Original languageEnglish
Pages (from-to)4-7
Number of pages4
JournalJournal of Surgical Oncology
Volume40
Issue number1
DOIs
Publication statusPublished - Jan 1 1989

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Carbazilquinone
Aclarubicin
Mitomycin
Neoplasms
Succinate Dehydrogenase
In Vitro Techniques
Colectomy
Poisons
Gastrectomy
Antineoplastic Agents
Stomach
Mucous Membrane

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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Tumor tissue is more sensitive to mitomycin C, carboquone, and aclacinomycin A than is adjacent normal tissue in vitro. / Maehara, Yoshihiko; Kusumoto, Hiroki; Kusumoto, Tetsuya; Anai, Hideaki; Sugimachi, Keizo.

In: Journal of Surgical Oncology, Vol. 40, No. 1, 01.01.1989, p. 4-7.

Research output: Contribution to journalArticle

Maehara, Yoshihiko ; Kusumoto, Hiroki ; Kusumoto, Tetsuya ; Anai, Hideaki ; Sugimachi, Keizo. / Tumor tissue is more sensitive to mitomycin C, carboquone, and aclacinomycin A than is adjacent normal tissue in vitro. In: Journal of Surgical Oncology. 1989 ; Vol. 40, No. 1. pp. 4-7.
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abstract = "In tissues obtained from patients undergoing gastrectomy or colectomy, sensitivity to mitomycin C (MMC), carboquone (CQ), and aclacinomycin A (ACR) was examined in 20 tumors (15 gastric, 5 colorectal) and in the adjacent normal mucosal tissues, using the in vitro succinate dehydrogenase inhibition test. The succinate dehydrogenase (SD) activity decreased to a greater extent in the tumor tissues than in adjacent normal tissues, at rates of 80{\%} for MMC, 80{\%} for CQ, and 90{\%} for ACR. There were no correlations between SD activities of tumor and adjacent normal tissue, r = 0.157 for MMC, r = 0.435 for CQ, and r = 0.375 for ACR. Normal tissues were sensitive to MMC in 25 {\%} of cases sensitive to MMC in the tumor tissues, 46{\%} for CQ, and 38{\%} for ACR. These results show that the antitumor effects of MMC, CQ, and ACR are relatively specific for tumor tissues and that the assay of chemosensitivity of normal tissues is meaningful for predicting the toxic effects of antitumor drugs on these tissues.",
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